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Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone.
Forrest MJ, Bloomfield D, Briscoe RJ, Brown PN, Cumiskey AM, Ehrhart J, Hershey JC, Keller WJ, Ma X, McPherson HE, Messina E, Peterson LB, Sharif-Rodriguez W, Siegl PK, Sinclair PJ, Sparrow CP, Stevenson AS, Sun SY, Tsai C, Vargas H, Walker M 3rd, West SH, White V, Woltmann RF. Forrest MJ, et al. Among authors: briscoe rj. Br J Pharmacol. 2008 Aug;154(7):1465-73. doi: 10.1038/bjp.2008.229. Epub 2008 Jun 9. Br J Pharmacol. 2008. PMID: 18536749 Free PMC article.
Cardiovascular monkey telemetry: sensitivity to detect QT interval prolongation.
Chaves AA, Keller WJ, O'Sullivan S, Williams MA, Fitzgerald LE, McPherson HE, Goykhman D, Ward PD, Hoe CM, Mixson L, Briscoe RJ. Chaves AA, et al. Among authors: briscoe rj. J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):150-8. doi: 10.1016/j.vascn.2006.03.004. Epub 2006 Mar 27. J Pharmacol Toxicol Methods. 2006. PMID: 16679034
A highly sensitive canine telemetry model for detection of QT interval prolongation: studies with moxifloxacin, haloperidol and MK-499.
Chaves AA, Zingaro GJ, Yordy MA, Bustard KA, O'Sullivan S, Galijatovic-Idrizbegovic A, Schuck H, Christian DB, Hoe CM, Briscoe RJ. Chaves AA, et al. Among authors: briscoe rj. J Pharmacol Toxicol Methods. 2007 Sep-Oct;56(2):103-14. doi: 10.1016/j.vascn.2007.04.007. Epub 2007 May 24. J Pharmacol Toxicol Methods. 2007. PMID: 17643323
Benchmarking safety pharmacology regulatory packages and best practice.
Lindgren S, Bass AS, Briscoe R, Bruse K, Friedrichs GS, Kallman MJ, Markgraf C, Patmore L, Pugsley MK. Lindgren S, et al. J Pharmacol Toxicol Methods. 2008 Sep-Oct;58(2):99-109. doi: 10.1016/j.vascn.2008.07.001. Epub 2008 Jul 19. J Pharmacol Toxicol Methods. 2008. PMID: 18692579
35 results