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Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist.
J Med Chem. 2008 Jul 10;51(13):3692-5. doi: 10.1021/jm800419w. Epub 2008 Jun 10.
J Med Chem. 2008.
PMID: 18540666
Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.
Yang ZQ, Barrow JC, Shipe WD, Schlegel KA, Shu Y, Yang FV, Lindsley CW, Rittle KE, Bock MG, Hartman GD, Uebele VN, Nuss CE, Fox SV, Kraus RL, Doran SM, Connolly TM, Tang C, Ballard JE, Kuo Y, Adarayan ED, Prueksaritanont T, Zrada MM, Marino MJ, Graufelds VK, DiLella AG, Reynolds IJ, Vargas HM, Bunting PB, Woltmann RF, Magee MM, Koblan KS, Renger JJ.
Yang ZQ, et al. Among authors: adarayan ed.
J Med Chem. 2008 Oct 23;51(20):6471-7. doi: 10.1021/jm800830n. Epub 2008 Sep 26.
J Med Chem. 2008.
PMID: 18817368
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Pharmacological validation of a novel nonhuman primate measure of thermal responsivity with utility for predicting analgesic effects.
Vardigan JD, Houghton AK, Lange HS, Adarayan ED, Pall PS, Ballard JE, Henze DA, Uslaner JM.
Vardigan JD, et al. Among authors: adarayan ed.
J Pain Res. 2018 Apr 11;11:735-741. doi: 10.2147/JPR.S152879. eCollection 2018.
J Pain Res. 2018.
PMID: 29692626
Free PMC article.
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Quantitation of geometric isomers of a phosphodiesterase inhibitor in rat and monkey plasma using liquid chromatography-tandem mass spectrometry.
Liang Y, Zhang R, Adarayan E, Adamson G, Zhao JJ, Kassahun K, Emary WB.
Liang Y, et al.
J Pharm Biomed Anal. 2006 Jun 16;41(4):1293-8. doi: 10.1016/j.jpba.2006.02.016. Epub 2006 Mar 23.
J Pharm Biomed Anal. 2006.
PMID: 16563689
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