Hamel E - Search Results

1

Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198.

LaVallee TM, Burke PA, Swartz GM, Hamel E, Agoston GE, Shah J, Suwandi L, Hanson AD, Fogler WE, Sidor CF, Treston AM. LaVallee TM, et al. Among authors: hamel e. Mol Cancer Ther. 2008 Jun;7(6):1472-82. doi: 10.1158/1535-7163.MCT-08-0107. Mol Cancer Ther. 2008. PMID: 18566218

2

Effects of altering the electronics of 2-methoxyestradiol on cell proliferation, on cytotoxicity in human cancer cell cultures, and on tubulin polymerization.

Edsall AB, Mohanakrishnan AK, Yang D, Fanwick PE, Hamel E, Hanson AD, Agoston GE, Cushman M. Edsall AB, et al. Among authors: hamel e. J Med Chem. 2004 Oct 7;47(21):5126-39. doi: 10.1021/jm049647a. J Med Chem. 2004. PMID: 15456256

3

Development of two novel benzoylphenylurea sulfur analogues and evidence that the microtubule-associated protein tau is predictive of their activity in pancreatic cancer.

Jimeno A, Hallur G, Chan A, Zhang X, Cusatis G, Chan F, Shah P, Chen R, Hamel E, Garrett-Mayer E, Khan S, Hidalgo M. Jimeno A, et al. Among authors: hamel e. Mol Cancer Ther. 2007 May;6(5):1509-16. doi: 10.1158/1535-7163.MCT-06-0592. Epub 2007 May 4. Mol Cancer Ther. 2007. PMID: 17483439

4

Stereoselective synthesis of 3,3-diarylacrylonitriles as tubulin polymerization inhibitors.

Fang Z, Song Y, Sarkar T, Hamel E, Fogler WE, Agoston GE, Fanwick PE, Cushman M. Fang Z, et al. Among authors: hamel e. J Org Chem. 2008 Jun 6;73(11):4241-4. doi: 10.1021/jo800428b. Epub 2008 May 1. J Org Chem. 2008. PMID: 18447388

5

A bifunctional colchicinoid that binds to the androgen receptor.

Sharifi N, Hamel E, Lill MA, Risbood P, Kane CT Jr, Hossain MT, Jones A, Dalton JT, Farrar WL. Sharifi N, et al. Among authors: hamel e. Mol Cancer Ther. 2007 Aug;6(8):2328-36. doi: 10.1158/1535-7163.MCT-07-0163. Mol Cancer Ther. 2007. PMID: 17699728

6

The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity.

Xiang W, Quadery TM, Hamel E, Luckett-Chastain LR, Ihnat MA, Mooberry SL, Gangjee A. Xiang W, et al. Among authors: hamel e. Bioorg Med Chem. 2021 Jan 1;29:115887. doi: 10.1016/j.bmc.2020.115887. Epub 2020 Nov 24. Bioorg Med Chem. 2021. PMID: 33310545 Free PMC article.

7

Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin.

Cruz-Monserrate Z, Vervoort HC, Bai R, Newman DJ, Howell SB, Los G, Mullaney JT, Williams MD, Pettit GR, Fenical W, Hamel E. Cruz-Monserrate Z, et al. Among authors: hamel e. Mol Pharmacol. 2003 Jun;63(6):1273-80. doi: 10.1124/mol.63.6.1273. Mol Pharmacol. 2003. PMID: 12761336

8

Structure based drug design and in vitro metabolism study: Discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent.

Xiang W, Choudhary S, Hamel E, Mooberry SL, Gangjee A. Xiang W, et al. Among authors: hamel e. Bioorg Med Chem. 2018 May 15;26(9):2437-2451. doi: 10.1016/j.bmc.2018.04.010. Epub 2018 Apr 4. Bioorg Med Chem. 2018. PMID: 29655610 Free PMC article.

9

Design, synthesis, and structure-activity relationships of pyrimido[4,5-b]indole-4-amines as microtubule depolymerizing agents that are effective against multidrug resistant cells.

Devambatla RKV, Li W, Zaware N, Choudhary S, Hamel E, Mooberry SL, Gangjee A. Devambatla RKV, et al. Among authors: hamel e. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3423-3430. doi: 10.1016/j.bmcl.2017.05.085. Epub 2017 May 27. Bioorg Med Chem Lett. 2017. PMID: 28610978 Free PMC article.

10

Evading Pgp activity in drug-resistant cancer cells: a structural and functional study of antitubulin furan metotica compounds.

Nguyen TL, Cera MR, Pinto A, Lo Presti L, Hamel E, Conti P, Gussio R, De Wulf P. Nguyen TL, et al. Among authors: hamel e. Mol Cancer Ther. 2012 May;11(5):1103-11. doi: 10.1158/1535-7163.MCT-11-1018. Epub 2012 Mar 21. Mol Cancer Ther. 2012. PMID: 22442310 Free PMC article.

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