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Rethinking pseudokinases.
Kannan N, Taylor SS. Kannan N, et al. Cell. 2008 Apr 18;133(2):204-5. doi: 10.1016/j.cell.2008.04.005. Cell. 2008. PMID: 18423189 Free PMC article.
The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail.
Gould CM, Kannan N, Taylor SS, Newton AC. Gould CM, et al. Among authors: kannan n. J Biol Chem. 2009 Feb 20;284(8):4921-35. doi: 10.1074/jbc.M808436200. Epub 2008 Dec 17. J Biol Chem. 2009. PMID: 19091746 Free PMC article.
The life cycle of protein kinase C (PKC) is tightly controlled by mechanisms that mature the enzyme, sustain the activation-competent enzyme, and degrade the enzyme. Here we show that a conserved PXXP motif (Kannan, N., Haste, N., Taylor, S. S., and Neuwald, …
The life cycle of protein kinase C (PKC) is tightly controlled by mechanisms that mature the enzyme, sustain the activation-competent enzyme …
451 results