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Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone.
Hoffmann J, Vitale I, Buchmann B, Galluzzi L, Schwede W, Senovilla L, Skuballa W, Vivet S, Lichtner RB, Vicencio JM, Panaretakis T, Siemeister G, Lage H, Nanty L, Hammer S, Mittelstaedt K, Winsel S, Eschenbrenner J, Castedo M, Demarche C, Klar U, Kroemer G. Hoffmann J, et al. Among authors: mittelstaedt k. Cancer Res. 2008 Jul 1;68(13):5301-8. doi: 10.1158/0008-5472.CAN-08-0237. Cancer Res. 2008. PMID: 18593931
Evaluation of activity and combination strategies with the microtubule-targeting drug sagopilone in breast cancer cell lines.
Eschenbrenner J, Winsel S, Hammer S, Sommer A, Mittelstaedt K, Drosch M, Klar U, Sachse C, Hannus M, Seidel M, Weiss B, Merz C, Siemeister G, Hoffmann J. Eschenbrenner J, et al. Among authors: mittelstaedt k. Front Oncol. 2011 Nov 16;1:44. doi: 10.3389/fonc.2011.00044. eCollection 2011. Front Oncol. 2011. PMID: 22649765 Free PMC article.
Biomolecular analyses enable new insights into ancient Egyptian embalming.
Rageot M, Hussein RB, Beck S, Altmann-Wendling V, Ibrahim MIM, Bahgat MM, Yousef AM, Mittelstaedt K, Filippi JJ, Buckley S, Spiteri C, Stockhammer PW. Rageot M, et al. Among authors: mittelstaedt k. Nature. 2023 Feb;614(7947):287-293. doi: 10.1038/s41586-022-05663-4. Epub 2023 Feb 1. Nature. 2023. PMID: 36725928 Free PMC article.
LIM kinase 2 (LIMK2) may play an essential role in platelet function.
Antonipillai J, Mittelstaedt K, Rigby S, Bassler N, Bernard O. Antonipillai J, et al. Among authors: mittelstaedt k. Exp Cell Res. 2020 Mar 1;388(1):111822. doi: 10.1016/j.yexcr.2020.111822. Epub 2020 Jan 9. Exp Cell Res. 2020. PMID: 31926945