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Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
J Biol Chem. 2008 Sep 5;283(36):25046-56. doi: 10.1074/jbc.M803776200. Epub 2008 Jul 3.
J Biol Chem. 2008.
PMID: 18603530
Free PMC article.
AlkB demethylases flip out in different ways.
Sundheim O, Talstad VA, Vågbø CB, Slupphaug G, Krokan HE.
Sundheim O, et al. Among authors: talstad va.
DNA Repair (Amst). 2008 Nov 1;7(11):1916-23. doi: 10.1016/j.dnarep.2008.07.015. Epub 2008 Sep 6.
DNA Repair (Amst). 2008.
PMID: 18723127
Review.
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Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
Sundheim O, Vågbø CB, Bjørås M, Sousa MM, Talstad V, Aas PA, Drabløs F, Krokan HE, Tainer JA, Slupphaug G.
Sundheim O, et al.
EMBO J. 2006 Jul 26;25(14):3389-97. doi: 10.1038/sj.emboj.7601219. Epub 2006 Jul 6.
EMBO J. 2006.
PMID: 16858410
Free PMC article.
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Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.
Ringvoll J, Nordstrand LM, Vågbø CB, Talstad V, Reite K, Aas PA, Lauritzen KH, Liabakk NB, Bjørk A, Doughty RW, Falnes PØ, Krokan HE, Klungland A.
Ringvoll J, et al.
EMBO J. 2006 May 17;25(10):2189-98. doi: 10.1038/sj.emboj.7601109. Epub 2006 Apr 27.
EMBO J. 2006.
PMID: 16642038
Free PMC article.
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