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Intracellular mechanisms of specific beta-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure.
Bartholomeu JB, Vanzelli AS, Rolim NP, Ferreira JC, Bechara LR, Tanaka LY, Rosa KT, Alves MM, Medeiros A, Mattos KC, Coelho MA, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Ramires PR, Guatimosim S, Brum PC. Bartholomeu JB, et al. Among authors: guatimosim s. J Mol Cell Cardiol. 2008 Aug;45(2):240-9. doi: 10.1016/j.yjmcc.2008.05.011. Epub 2008 May 27. J Mol Cell Cardiol. 2008. PMID: 18632114
Integrative effect of carvedilol and aerobic exercise training therapies on improving cardiac contractility and remodeling in heart failure mice.
Vanzelli AS, Medeiros A, Rolim N, Bartholomeu JB, Cunha TF, Bechara LR, Gomes ER, Mattos KC, Sirvente R, Salemi VM, Mady C, Negrao CE, Guatimosim S, Brum PC. Vanzelli AS, et al. Among authors: guatimosim s. PLoS One. 2013 May 1;8(5):e62452. doi: 10.1371/journal.pone.0062452. Print 2013. PLoS One. 2013. PMID: 23658728 Free PMC article.
Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure.
Campos JC, Queliconi BB, Bozi LHM, Bechara LRG, Dourado PMM, Andres AM, Jannig PR, Gomes KMS, Zambelli VO, Rocha-Resende C, Guatimosim S, Brum PC, Mochly-Rosen D, Gottlieb RA, Kowaltowski AJ, Ferreira JCB. Campos JC, et al. Among authors: guatimosim s. Autophagy. 2017 Aug 3;13(8):1304-1317. doi: 10.1080/15548627.2017.1325062. Autophagy. 2017. PMID: 28598232 Free PMC article.
Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure.
Lara A, Damasceno DD, Pires R, Gros R, Gomes ER, Gavioli M, Lima RF, Guimarães D, Lima P, Bueno CR Jr, Vasconcelos A, Roman-Campos D, Menezes CA, Sirvente RA, Salemi VM, Mady C, Caron MG, Ferreira AJ, Brum PC, Resende RR, Cruz JS, Gomez MV, Prado VF, de Almeida AP, Prado MA, Guatimosim S. Lara A, et al. Among authors: guatimosim s. Mol Cell Biol. 2010 Apr;30(7):1746-56. doi: 10.1128/MCB.00996-09. Epub 2010 Feb 1. Mol Cell Biol. 2010. PMID: 20123977 Free PMC article.
Cholinergic signaling exerts protective effects in models of sympathetic hyperactivity-induced cardiac dysfunction.
Gavioli M, Lara A, Almeida PW, Lima AM, Damasceno DD, Rocha-Resende C, Ladeira M, Resende RR, Martinelli PM, Melo MB, Brum PC, Fontes MA, Souza Santos RA, Prado MA, Guatimosim S. Gavioli M, et al. Among authors: guatimosim s. PLoS One. 2014 Jul 3;9(7):e100179. doi: 10.1371/journal.pone.0100179. eCollection 2014. PLoS One. 2014. PMID: 24992197 Free PMC article.
Resistance exercise mediates remote ischemic preconditioning by limiting cardiac eNOS uncoupling.
Santana MNS, Souza DS, Miguel-Dos-Santos R, Rabelo TK, Vasconcelos CML, Navia-Pelaez JM, Jesus ICG, Silva-Neto JAD, Lauton-Santos S, Capettini LDSA, Guatimosim S, Rogers RG, Santos MRVD, Santana-Filho VJ, Mesquita TRR. Santana MNS, et al. Among authors: guatimosim s. J Mol Cell Cardiol. 2018 Dec;125:61-72. doi: 10.1016/j.yjmcc.2018.10.016. Epub 2018 Oct 16. J Mol Cell Cardiol. 2018. PMID: 30339842
Dissection of the Effects of Quercetin on Mouse Myocardium.
Santos MS, Oliveira ED, Santos-Miranda A, Cruz JS, Gondim ANS, Menezes-Filho JER, Souza DS, Pinho-da-Silva L, Jesus ICG, Roman-Campos D, Guatimosim S, Lara A, Conde-Garcia EA, Vasconcelos CML. Santos MS, et al. Among authors: guatimosim s. Basic Clin Pharmacol Toxicol. 2017 Jun;120(6):550-559. doi: 10.1111/bcpt.12743. Epub 2017 Mar 14. Basic Clin Pharmacol Toxicol. 2017. PMID: 27992670 Free article.
Non-neuronal cholinergic machinery present in cardiomyocytes offsets hypertrophic signals.
Rocha-Resende C, Roy A, Resende R, Ladeira MS, Lara A, de Morais Gomes ER, Prado VF, Gros R, Guatimosim C, Prado MA, Guatimosim S. Rocha-Resende C, et al. Among authors: guatimosim c, guatimosim s. J Mol Cell Cardiol. 2012 Aug;53(2):206-16. doi: 10.1016/j.yjmcc.2012.05.003. Epub 2012 May 14. J Mol Cell Cardiol. 2012. PMID: 22587993 Free PMC article.
125 results