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Extracellular loop C of NPC1L1 is important for binding to ezetimibe.
Weinglass AB, Kohler M, Schulte U, Liu J, Nketiah EO, Thomas A, Schmalhofer W, Williams B, Bildl W, McMasters DR, Dai K, Beers L, McCann ME, Kaczorowski GJ, Garcia ML. Weinglass AB, et al. Among authors: kaczorowski gj. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11140-5. doi: 10.1073/pnas.0800936105. Epub 2008 Aug 5. Proc Natl Acad Sci U S A. 2008. PMID: 18682566 Free PMC article.
Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake.
Weinglass AB, Köhler MG, Nketiah EO, Liu J, Schmalhofer W, Thomas A, Williams B, Beers L, Smith L, Hafey M, Bleasby K, Leone J, Tang YS, Braun M, Ujjainwalla F, McCann ME, Kaczorowski GJ, Garcia ML. Weinglass AB, et al. Among authors: kaczorowski gj. Mol Pharmacol. 2008 Apr;73(4):1072-84. doi: 10.1124/mol.107.043844. Epub 2008 Jan 10. Mol Pharmacol. 2008. PMID: 18187582
Ion channels find a pathway for therapeutic success.
Garcia ML, Kaczorowski GJ. Garcia ML, et al. Among authors: kaczorowski gj. Proc Natl Acad Sci U S A. 2016 May 17;113(20):5472-4. doi: 10.1073/pnas.1605669113. Epub 2016 May 4. Proc Natl Acad Sci U S A. 2016. PMID: 27147602 Free PMC article. No abstract available.
181 results