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The antidepressant sertraline downregulates Akt and has activity against melanoma cells.
Reddy KK, Lefkove B, Chen LB, Govindarajan B, Carracedo A, Velasco G, Carrillo CO, Bhandarkar SS, Owens MJ, Mechta-Grigoriou F, Arbiser JL. Reddy KK, et al. Among authors: velasco g. Pigment Cell Melanoma Res. 2008 Aug;21(4):451-6. doi: 10.1111/j.1755-148X.2008.00481.x. Pigment Cell Melanoma Res. 2008. PMID: 18710373
The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells.
Carracedo A, Lorente M, Egia A, Blázquez C, García S, Giroux V, Malicet C, Villuendas R, Gironella M, González-Feria L, Piris MA, Iovanna JL, Guzmán M, Velasco G. Carracedo A, et al. Among authors: velasco g. Cancer Cell. 2006 Apr;9(4):301-12. doi: 10.1016/j.ccr.2006.03.005. Cancer Cell. 2006. PMID: 16616335 Free article.
Cannabinoid receptors as novel targets for the treatment of melanoma.
Blázquez C, Carracedo A, Barrado L, Real PJ, Fernández-Luna JL, Velasco G, Malumbres M, Guzmán M. Blázquez C, et al. Among authors: velasco g. FASEB J. 2006 Dec;20(14):2633-5. doi: 10.1096/fj.06-6638fje. Epub 2006 Oct 25. FASEB J. 2006. PMID: 17065222
p8 Upregulation sensitizes astrocytes to oxidative stress.
Carracedo A, Egia A, Guzmán M, Velasco G. Carracedo A, et al. Among authors: velasco g. FEBS Lett. 2006 Mar 6;580(6):1571-5. doi: 10.1016/j.febslet.2006.01.084. Epub 2006 Feb 9. FEBS Lett. 2006. PMID: 16480983 Free article.
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells.
Salazar M, Carracedo A, Salanueva IJ, Hernández-Tiedra S, Lorente M, Egia A, Vázquez P, Blázquez C, Torres S, García S, Nowak J, Fimia GM, Piacentini M, Cecconi F, Pandolfi PP, González-Feria L, Iovanna JL, Guzmán M, Boya P, Velasco G. Salazar M, et al. Among authors: velasco g. J Clin Invest. 2009 May;119(5):1359-72. doi: 10.1172/jci37948. J Clin Invest. 2009. PMID: 19425170 Free PMC article.
364 results