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Structural aberrations affecting the MYC locus indicate a poor prognosis independent of clinical risk factors in diffuse large B-cell lymphomas treated within randomized trials of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL).
Klapper W, Stoecklein H, Zeynalova S, Ott G, Kosari F, Rosenwald A, Loeffler M, Trümper L, Pfreundschuh M, Siebert R; German High-Grade Non-Hodgkin's Lymphoma Study Group. Klapper W, et al. Among authors: loeffler m. Leukemia. 2008 Dec;22(12):2226-9. doi: 10.1038/leu.2008.230. Epub 2008 Aug 28. Leukemia. 2008. PMID: 18754028
A novel lymphoma-associated macrophage interaction signature (LAMIS) provides robust risk prognostication in diffuse large B-cell lymphoma clinical trial cohorts of the DSHNHL.
Staiger AM, Altenbuchinger M, Ziepert M, Kohler C, Horn H, Huttner M, Hüttl KS, Glehr G, Klapper W, Szczepanowski M, Richter J, Stein H, Feller AC, Möller P, Hansmann ML, Poeschel V, Held G, Loeffler M, Schmitz N, Trümper L, Pukrop T, Rosenwald A, Ott G, Spang R; Emed Demonstrator Project; German High Grade Non-Hodgkin’s Lymphoma Study Group (DSHNHL). Staiger AM, et al. Among authors: loeffler m. Leukemia. 2020 Feb;34(2):543-552. doi: 10.1038/s41375-019-0573-y. Epub 2019 Sep 17. Leukemia. 2020. PMID: 31530861 Clinical Trial.
Pathway activation patterns in diffuse large B-cell lymphomas.
Bentink S, Wessendorf S, Schwaenen C, Rosolowski M, Klapper W, Rosenwald A, Ott G, Banham AH, Berger H, Feller AC, Hansmann ML, Hasenclever D, Hummel M, Lenze D, Möller P, Stuerzenhofecker B, Loeffler M, Truemper L, Stein H, Siebert R, Spang R; Molecular Mechanisms in Malignant Lymphomas Network Project of the. Bentink S, et al. Among authors: loeffler m. Leukemia. 2008 Sep;22(9):1746-54. doi: 10.1038/leu.2008.166. Epub 2008 Jun 26. Leukemia. 2008. PMID: 18580954
Different biological risk factors in young poor-prognosis and elderly patients with diffuse large B-cell lymphoma.
Horn H, Ziepert M, Wartenberg M, Staiger AM, Barth TF, Bernd HW, Feller AC, Klapper W, Stuhlmann-Laeisz C, Hummel M, Stein H, Lenze D, Hartmann S, Hansmann ML, Möller P, Cogliatti S, Pfreundschuh M, Trümper L, Loeffler M, Glass B, Schmitz N, Ott G, Rosenwald A; DSHNHL16. Horn H, et al. Among authors: loeffler m. Leukemia. 2015 Jul;29(7):1564-70. doi: 10.1038/leu.2015.43. Epub 2015 Feb 17. Leukemia. 2015. PMID: 25687653
SPARC-positive macrophages are the superior prognostic factor in the microenvironment of diffuse large B-cell lymphoma and independent of MYC rearrangement and double-/triple-hit status.
Croci GA, Au-Yeung RKH, Reinke S, Staiger AM, Koch K, Oschlies I, Richter J, Poeschel V, Held G, Loeffler M, Trümper L, Rosenwald A, Ott G, Spang R, Altmann B, Ziepert M, Klapper W. Croci GA, et al. Among authors: loeffler m. Ann Oncol. 2021 Nov;32(11):1400-1409. doi: 10.1016/j.annonc.2021.08.1991. Epub 2021 Aug 24. Ann Oncol. 2021. PMID: 34438040 Free article.
Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma.
Aukema SM, Kreuz M, Kohler CW, Rosolowski M, Hasenclever D, Hummel M, Küppers R, Lenze D, Ott G, Pott C, Richter J, Rosenwald A, Szczepanowski M, Schwaenen C, Stein H, Trautmann H, Wessendorf S, Trümper L, Loeffler M, Spang R, Kluin PM, Klapper W, Siebert R; Molecular Mechanisms in Malignant Lymphomas Network Project. Aukema SM, et al. Among authors: loeffler m. Haematologica. 2014 Apr;99(4):726-35. doi: 10.3324/haematol.2013.091827. Epub 2013 Oct 31. Haematologica. 2014. PMID: 24179151 Free PMC article.
Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial.
Schoof N, von Bonin F, Zeynalova S, Ziepert M, Jung W, Loeffler M, Pfreundschuh M, Trümper L, Kube D. Schoof N, et al. Among authors: loeffler m. Ann Oncol. 2009 Sep;20(9):1548-1554. doi: 10.1093/annonc/mdp110. Epub 2009 Jun 10. Ann Oncol. 2009. PMID: 19515749 Free article. Clinical Trial.
High-dose therapy followed by autologous stem-cell transplantation with and without rituximab for primary treatment of high-risk diffuse large B-cell lymphoma.
Glass B, Ziepert M, Reiser M, Freund M, Trümper L, Metzner B, Feller A, Loeffler M, Pfreundschuh M, Schmitz N; German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL). Glass B, et al. Among authors: loeffler m. Ann Oncol. 2010 Nov;21(11):2255-2261. doi: 10.1093/annonc/mdq235. Epub 2010 May 5. Ann Oncol. 2010. PMID: 20444844 Free article.
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