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Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis.
Nguyên TL, Abdelbary H, Arguello M, Breitbach C, Leveille S, Diallo JS, Yasmeen A, Bismar TA, Kirn D, Falls T, Snoulten VE, Vanderhyden BC, Werier J, Atkins H, Vähä-Koskela MJ, Stojdl DF, Bell JC, Hiscott J. Nguyên TL, et al. Among authors: vanderhyden bc. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14981-6. doi: 10.1073/pnas.0803988105. Epub 2008 Sep 24. Proc Natl Acad Sci U S A. 2008. PMID: 18815361 Free PMC article.
Comparative analysis of syngeneic mouse models of high-grade serous ovarian cancer.
Cook DP, Galpin KJC, Rodriguez GM, Shakfa N, Wilson-Sanchez J, Echaibi M, Pereira M, Matuszewska K, Haagsma J, Murshed H, Cudmore AO, MacDonald E, Tone A, Shepherd TG, Petrik JJ, Koti M, Vanderhyden BC. Cook DP, et al. Among authors: vanderhyden bc. Commun Biol. 2023 Nov 13;6(1):1152. doi: 10.1038/s42003-023-05529-z. Commun Biol. 2023. PMID: 37957414 Free PMC article.
The oncolytic poxvirus JX-594 selectively replicates in and destroys cancer cells driven by genetic pathways commonly activated in cancers.
Parato KA, Breitbach CJ, Le Boeuf F, Wang J, Storbeck C, Ilkow C, Diallo JS, Falls T, Burns J, Garcia V, Kanji F, Evgin L, Hu K, Paradis F, Knowles S, Hwang TH, Vanderhyden BC, Auer R, Kirn DH, Bell JC. Parato KA, et al. Among authors: vanderhyden bc. Mol Ther. 2012 Apr;20(4):749-58. doi: 10.1038/mt.2011.276. Epub 2011 Dec 20. Mol Ther. 2012. PMID: 22186794 Free PMC article.
Harnessing oncolytic virus-mediated antitumor immunity in an infected cell vaccine.
Lemay CG, Rintoul JL, Kus A, Paterson JM, Garcia V, Falls TJ, Ferreira L, Bridle BW, Conrad DP, Tang VA, Diallo JS, Arulanandam R, Le Boeuf F, Garson K, Vanderhyden BC, Stojdl DF, Lichty BD, Atkins HL, Parato KA, Bell JC, Auer RC. Lemay CG, et al. Among authors: vanderhyden bc. Mol Ther. 2012 Sep;20(9):1791-9. doi: 10.1038/mt.2012.128. Epub 2012 Jul 3. Mol Ther. 2012. PMID: 22760544 Free PMC article.
Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing.
Arulanandam R, Batenchuk C, Varette O, Zakaria C, Garcia V, Forbes NE, Davis C, Krishnan R, Karmacharya R, Cox J, Sinha A, Babawy A, Waite K, Weinstein E, Falls T, Chen A, Hamill J, De Silva N, Conrad DP, Atkins H, Garson K, Ilkow C, Kærn M, Vanderhyden B, Sonenberg N, Alain T, Le Boeuf F, Bell JC, Diallo JS. Arulanandam R, et al. Nat Commun. 2015 Mar 30;6:6410. doi: 10.1038/ncomms7410. Nat Commun. 2015. PMID: 25817275 Free article.
Enhancing Expression of Functional Human Sodium Iodide Symporter and Somatostatin Receptor in Recombinant Oncolytic Vaccinia Virus for In Vivo Imaging of Tumors.
Wang J, Arulanandam R, Wassenaar R, Falls T, Petryk J, Paget J, Garson K, Cemeus C, Vanderhyden BC, Wells RG, Bell JC, Le Boeuf F. Wang J, et al. Among authors: vanderhyden bc. J Nucl Med. 2017 Feb;58(2):221-227. doi: 10.2967/jnumed.116.180463. Epub 2016 Sep 15. J Nucl Med. 2017. PMID: 27635026 Free article.
Fatty acid transport protein inhibition sensitizes breast and ovarian cancers to oncolytic virus therapy via lipid modulation of the tumor microenvironment.
Surendran A, Jamalkhah M, Poutou J, Birtch R, Lawson C, Dave J, Crupi MJF, Mayer J, Taylor V, Petryk J, de Souza CT, Moodie N, Billingsley JL, Austin B, Cormack N, Blamey N, Rezaei R, McCloskey CW, Fekete EEF, Birdi HK, Neault S, Jamieson TR, Wylie B, Tucker S, Azad T, Vanderhyden B, Tai LH, Bell JC, Ilkow CS. Surendran A, et al. Front Immunol. 2023 Mar 10;14:1099459. doi: 10.3389/fimmu.2023.1099459. eCollection 2023. Front Immunol. 2023. PMID: 36969187 Free PMC article.
157 results