Heckroth H - Search Results

1

Design and synthesis of potent and selective azaindole-based Rho kinase (ROCK) inhibitors.

Schirok H, Kast R, Figueroa-Pérez S, Bennabi S, Gnoth MJ, Feurer A, Heckroth H, Thutewohl M, Paulsen H, Knorr A, Hütter J, Lobell M, Münter K, Geiss V, Ehmke H, Lang D, Radtke M, Mittendorf J, Stasch JP. Schirok H, et al. Among authors: heckroth h. ChemMedChem. 2008 Dec;3(12):1893-904. doi: 10.1002/cmdc.200800211. ChemMedChem. 2008. PMID: 18973168

2

Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases.

Bärfacker L, Kuhl A, Hillisch A, Grosser R, Figueroa-Pérez S, Heckroth H, Nitsche A, Ergüden JK, Gielen-Haertwig H, Schlemmer KH, Mittendorf J, Paulsen H, Platzek J, Kolkhof P. Bärfacker L, et al. Among authors: heckroth h. ChemMedChem. 2012 Aug;7(8):1385-403. doi: 10.1002/cmdc.201200081. Epub 2012 Jul 12. ChemMedChem. 2012. PMID: 22791416

3

Minor structural modifications convert a selective PPARalpha agonist into a potent, highly selective PPARdelta agonist.

Weigand S, Bischoff H, Dittrich-Wengenroth E, Heckroth H, Lang D, Vaupel A, Woltering M. Weigand S, et al. Among authors: heckroth h. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4619-23. doi: 10.1016/j.bmcl.2005.06.023. Bioorg Med Chem Lett. 2005. PMID: 16115765

4

The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents.

van der Staay FJ, Rutten K, Bärfacker L, Devry J, Erb C, Heckroth H, Karthaus D, Tersteegen A, van Kampen M, Blokland A, Prickaerts J, Reymann KG, Schröder UH, Hendrix M. van der Staay FJ, et al. Among authors: heckroth h. Neuropharmacology. 2008 Oct;55(5):908-18. doi: 10.1016/j.neuropharm.2008.07.005. Epub 2008 Jul 12. Neuropharmacology. 2008. PMID: 18674549

5

Alpha-carbonyl substituent effect on the lifetimes of triplet 1,4-biradicals from Norrish-Type-II reactions.

Cai X, Cygon P, Goldfuss B, Griesbeck AG, Heckroth H, Fujitsuka M, Majima T. Cai X, et al. Among authors: heckroth h. Chemistry. 2006 Jun 2;12(17):4662-7. doi: 10.1002/chem.200600011. Chemistry. 2006. PMID: 16557627

6

Photofragmentation of C,N-protected alpha-amino acids: comparing tert-leucine with sulfur-containing amino acids methionine and cysteine.

Griesbeck AG, Heckroth H. Griesbeck AG, et al. Among authors: heckroth h. Photochem Photobiol Sci. 2003 Nov;2(11):1130-3. doi: 10.1039/b307658j. Photochem Photobiol Sci. 2003. PMID: 14690225

7

Stereoselective synthesis of 2-aminocyclobutanols via photocyclization of alpha-amido alkylaryl ketones: mechanistic implications for the Norrish/Yang reaction.

Griesbeck AG, Heckroth H. Griesbeck AG, et al. Among authors: heckroth h. J Am Chem Soc. 2002 Jan 23;124(3):396-403. doi: 10.1021/ja0111941. J Am Chem Soc. 2002. PMID: 11792208

8

Keto-enol/enolate equilibria in the N-acetylamino-p-methylacetophenone system. Effect of a beta-nitrogen substituent.

Chiang Y, Griesbeck AG, Heckroth H, Hellrung B, Kresge AJ, Meng Q, O'Donoghue AC, Richard JP, Wirz J. Chiang Y, et al. Among authors: heckroth h. J Am Chem Soc. 2001 Sep 19;123(37):8979-84. doi: 10.1021/ja0107529. J Am Chem Soc. 2001. PMID: 11552805

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