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Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice.
Alves M, Gil B, Villegas-Salmeron J, Salari V, Martins-Ferreira R, Arribas Blázquez M, Menéndez Méndez A, Da Rosa Gerbatin R, Smith J, de Diego-Garcia L, Conte G, David Sierra Marquez J, Merino Serrais P, Mitra M, Fernandez Martin A, Wang Y, Kesavan J, Melia C, Parras A, Beamer E, Zimmer B, Heiland M, Cavanagh B, Cipolat R, Morgan J, Teng X, Prehn JHM, Fabene P, Bertini G, Artalejo AR, Ballestar E, Nicke A, Olivos-Oré LA, Connolly NM, Henshall DC, Engel T. Alves M, et al. Among authors: kesavan j. Brain Behav Immun. 2024 May 20:S0889-1591(24)00413-6. doi: 10.1016/j.bbi.2024.05.023. Online ahead of print. Brain Behav Immun. 2024. PMID: 38777288 Free article.
Differential microRNA editing may drive target pathway switching in human temporal lobe epilepsy.
Lau KEH, Nguyen NT, Kesavan JC, Langa E, Fanning K, Brennan GP, Sanz-Rodriguez A, Villegas-Salmerón J, Yan Y, Venø MT, Mills JD, Rosenow F, Bauer S, Kjems J, Henshall DC. Lau KEH, et al. Among authors: kesavan jc. Brain Commun. 2024 Jan 3;6(1):fcad355. doi: 10.1093/braincomms/fcad355. eCollection 2024. Brain Commun. 2024. PMID: 38204971 Free PMC article.
MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control.
Heiland M, Connolly NMC, Mamad O, Nguyen NT, Kesavan JC, Langa E, Fanning K, Sanfeliu A, Yan Y, Su J, Venø MT, Costard LS, Neubert V, Engel T, Hill TDM, Freiman TM, Mahesh A, Tiwari VK, Rosenow F, Bauer S, Kjems J, Morris G, Henshall DC. Heiland M, et al. Among authors: kesavan jc. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2216658120. doi: 10.1073/pnas.2216658120. Epub 2023 Jul 18. Proc Natl Acad Sci U S A. 2023. PMID: 37463203 Free PMC article.
AntimiR targeting of microRNA-134 reduces seizures in a mouse model of Angelman syndrome.
Campbell A, Morris G, Sanfeliu A, Augusto J, Langa E, Kesavan JC, Nguyen NT, Conroy RM, Worm J, Kielpinski L, Jensen MA, Miller MT, Kremer T, Reschke CR, Henshall DC. Campbell A, et al. Among authors: kesavan jc. Mol Ther Nucleic Acids. 2022 Apr 20;28:514-529. doi: 10.1016/j.omtn.2022.04.009. eCollection 2022 Jun 14. Mol Ther Nucleic Acids. 2022. PMID: 35592499 Free PMC article.
29 results