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In vivo silencing of alpha-synuclein using naked siRNA.
Lewis J, Melrose H, Bumcrot D, Hope A, Zehr C, Lincoln S, Braithwaite A, He Z, Ogholikhan S, Hinkle K, Kent C, Toudjarska I, Charisse K, Braich R, Pandey RK, Heckman M, Maraganore DM, Crook J, Farrer MJ. Lewis J, et al. Among authors: melrose h. Mol Neurodegener. 2008 Nov 1;3:19. doi: 10.1186/1750-1326-3-19. Mol Neurodegener. 2008. PMID: 18976489 Free PMC article.
Parkinson's disease: a rethink of rodent models.
Melrose HL, Lincoln SJ, Tyndall GM, Farrer MJ. Melrose HL, et al. Exp Brain Res. 2006 Aug;173(2):196-204. doi: 10.1007/s00221-006-0461-3. Epub 2006 Apr 26. Exp Brain Res. 2006. PMID: 16639500 Review.
Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice.
Melrose HL, Dächsel JC, Behrouz B, Lincoln SJ, Yue M, Hinkle KM, Kent CB, Korvatska E, Taylor JP, Witten L, Liang YQ, Beevers JE, Boules M, Dugger BN, Serna VA, Gaukhman A, Yu X, Castanedes-Casey M, Braithwaite AT, Ogholikhan S, Yu N, Bass D, Tyndall G, Schellenberg GD, Dickson DW, Janus C, Farrer MJ. Melrose HL, et al. Neurobiol Dis. 2010 Dec;40(3):503-17. doi: 10.1016/j.nbd.2010.07.010. Epub 2010 Jul 24. Neurobiol Dis. 2010. PMID: 20659558 Free PMC article.
A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease.
Melrose HL, Kent CB, Taylor JP, Dachsel JC, Hinkle KM, Lincoln SJ, Mok SS, Culvenor JG, Masters CL, Tyndall GM, Bass DI, Ahmed Z, Andorfer CA, Ross OA, Wszolek ZK, Delldonne A, Dickson DW, Farrer MJ. Melrose HL, et al. Neuroscience. 2007 Jul 29;147(4):1047-58. doi: 10.1016/j.neuroscience.2007.05.027. Epub 2007 Jul 3. Neuroscience. 2007. PMID: 17611037
A comparative study of Lrrk2 function in primary neuronal cultures.
Dächsel JC, Behrouz B, Yue M, Beevers JE, Melrose HL, Farrer MJ. Dächsel JC, et al. Parkinsonism Relat Disord. 2010 Dec;16(10):650-5. doi: 10.1016/j.parkreldis.2010.08.018. Epub 2010 Sep 17. Parkinsonism Relat Disord. 2010. PMID: 20850369 Free PMC article.
LRRK2 phosphorylates novel tau epitopes and promotes tauopathy.
Bailey RM, Covy JP, Melrose HL, Rousseau L, Watkinson R, Knight J, Miles S, Farrer MJ, Dickson DW, Giasson BI, Lewis J. Bailey RM, et al. Acta Neuropathol. 2013 Dec;126(6):809-27. doi: 10.1007/s00401-013-1188-4. Epub 2013 Oct 11. Acta Neuropathol. 2013. PMID: 24113872 Free PMC article.
46 results