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STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk.
Abelson AK, Delgado-Vega AM, Kozyrev SV, Sánchez E, Velázquez-Cruz R, Eriksson N, Wojcik J, Linga Reddy MV, Lima G, D'Alfonso S, Migliaresi S, Baca V, Orozco L, Witte T, Ortego-Centeno N; AADEA group; Abderrahim H, Pons-Estel BA, Gutiérrez C, Suárez A, González-Escribano MF, Martin J, Alarcón-Riquelme ME. Abelson AK, et al. Among authors: orozco l. Ann Rheum Dis. 2009 Nov;68(11):1746-53. doi: 10.1136/ard.2008.097642. Epub 2008 Nov 19. Ann Rheum Dis. 2009. PMID: 19019891 Free PMC article.
Association of PDCD1 polymorphisms with childhood-onset systemic lupus erythematosus.
Velázquez-Cruz R, Orozco L, Espinosa-Rosales F, Carreño-Manjarrez R, Solís-Vallejo E, López-Lara ND, Ruiz-López IK, Rodríguez-Lozano AL, Estrada-Gil JK, Jiménez-Sánchez G, Baca V. Velázquez-Cruz R, et al. Among authors: orozco l. Eur J Hum Genet. 2007 Mar;15(3):336-41. doi: 10.1038/sj.ejhg.5201767. Epub 2007 Jan 17. Eur J Hum Genet. 2007. PMID: 17228327
MiR-146a polymorphism is associated with asthma but not with systemic lupus erythematosus and juvenile rheumatoid arthritis in Mexican patients.
Jiménez-Morales S, Gamboa-Becerra R, Baca V, Del Río-Navarro BE, López-Ley DY, Velázquez-Cruz R, Saldaña-Alvarez Y, Salas-Martínez G, Orozco L. Jiménez-Morales S, et al. Among authors: orozco l. Tissue Antigens. 2012 Oct;80(4):317-21. doi: 10.1111/j.1399-0039.2012.01929.x. Epub 2012 Jul 24. Tissue Antigens. 2012. PMID: 22823586
Tumor necrosis factor-alpha is a common genetic risk factor for asthma, juvenile rheumatoid arthritis, and systemic lupus erythematosus in a Mexican pediatric population.
Jiménez-Morales S, Velázquez-Cruz R, Ramírez-Bello J, Bonilla-González E, Romero-Hidalgo S, Escamilla-Guerrero G, Cuevas F, Espinosa-Rosales F, Martínez-Aguilar NE, Gómez-Vera J, Baca V, Orozco L. Jiménez-Morales S, et al. Among authors: orozco l. Hum Immunol. 2009 Apr;70(4):251-6. doi: 10.1016/j.humimm.2009.01.027. Epub 2009 Feb 4. Hum Immunol. 2009. PMID: 19480843
Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).
Han S, Kim-Howard X, Deshmukh H, Kamatani Y, Viswanathan P, Guthridge JM, Thomas K, Kaufman KM, Ojwang J, Rojas-Villarraga A, Baca V, Orozco L, Rhodes B, Choi CB, Gregersen PK, Merrill JT, James JA, Gaffney PM, Moser KL, Jacob CO, Kimberly RP, Harley JB, Bae SC, Anaya JM, Alarcón-Riquelme ME, Matsuda K, Vyse TJ, Nath SK. Han S, et al. Among authors: orozco l. Hum Mol Genet. 2009 Mar 15;18(6):1171-80. doi: 10.1093/hmg/ddp007. Epub 2009 Jan 6. Hum Mol Genet. 2009. PMID: 19129174 Free PMC article.
346 results