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Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis.
Li X, Ominsky MS, Warmington KS, Morony S, Gong J, Cao J, Gao Y, Shalhoub V, Tipton B, Haldankar R, Chen Q, Winters A, Boone T, Geng Z, Niu QT, Ke HZ, Kostenuik PJ, Simonet WS, Lacey DL, Paszty C. Li X, et al. Among authors: chen q. J Bone Miner Res. 2009 Apr;24(4):578-88. doi: 10.1359/jbmr.081206. J Bone Miner Res. 2009. PMID: 19049336 Free article.
Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2.
Oliner J, Min H, Leal J, Yu D, Rao S, You E, Tang X, Kim H, Meyer S, Han SJ, Hawkins N, Rosenfeld R, Davy E, Graham K, Jacobsen F, Stevenson S, Ho J, Chen Q, Hartmann T, Michaels M, Kelley M, Li L, Sitney K, Martin F, Sun JR, Zhang N, Lu J, Estrada J, Kumar R, Coxon A, Kaufman S, Pretorius J, Scully S, Cattley R, Payton M, Coats S, Nguyen L, Desilva B, Ndifor A, Hayward I, Radinsky R, Boone T, Kendall R. Oliner J, et al. Among authors: chen q. Cancer Cell. 2004 Nov;6(5):507-16. doi: 10.1016/j.ccr.2004.09.030. Cancer Cell. 2004. PMID: 15542434 Free article.
Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury.
Li X, Grisanti M, Fan W, Asuncion FJ, Tan HL, Dwyer D, Han CY, Yu L, Lee J, Lee E, Barrero M, Kurimoto P, Niu QT, Geng Z, Winters A, Horan T, Steavenson S, Jacobsen F, Chen Q, Haldankar R, Lavallee J, Tipton B, Daris M, Sheng J, Lu HS, Daris K, Deshpande R, Valente EG, Salimi-Moosavi H, Kostenuik PJ, Li J, Liu M, Li C, Lacey DL, Simonet WS, Ke HZ, Babij P, Stolina M, Ominsky MS, Richards WG. Li X, et al. Among authors: chen q. J Bone Miner Res. 2011 Nov;26(11):2610-21. doi: 10.1002/jbmr.472. J Bone Miner Res. 2011. PMID: 21773994 Free article.
A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair.
Florio M, Gunasekaran K, Stolina M, Li X, Liu L, Tipton B, Salimi-Moosavi H, Asuncion FJ, Li C, Sun B, Tan HL, Zhang L, Han CY, Case R, Duguay AN, Grisanti M, Stevens J, Pretorius JK, Pacheco E, Jones H, Chen Q, Soriano BD, Wen J, Heron B, Jacobsen FW, Brisan E, Richards WG, Ke HZ, Ominsky MS. Florio M, et al. Among authors: chen q. Nat Commun. 2016 May 27;7:11505. doi: 10.1038/ncomms11505. Nat Commun. 2016. PMID: 27230681 Free PMC article.
Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors.
Burgess T, Coxon A, Meyer S, Sun J, Rex K, Tsuruda T, Chen Q, Ho SY, Li L, Kaufman S, McDorman K, Cattley RC, Sun J, Elliott G, Zhang K, Feng X, Jia XC, Green L, Radinsky R, Kendall R. Burgess T, et al. Among authors: chen q. Cancer Res. 2006 Feb 1;66(3):1721-9. doi: 10.1158/0008-5472.CAN-05-3329. Cancer Res. 2006. PMID: 16452232
Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types.
Kaplan-Lefko PJ, Graves JD, Zoog SJ, Pan Y, Wall J, Branstetter DG, Moriguchi J, Coxon A, Huard JN, Xu R, Peach ML, Juan G, Kaufman S, Chen Q, Bianchi A, Kordich JJ, Ma M, Foltz IN, Gliniak BC. Kaplan-Lefko PJ, et al. Among authors: chen q. Cancer Biol Ther. 2010 Apr 15;9(8):618-31. doi: 10.4161/cbt.9.8.11264. Epub 2010 Apr 20. Cancer Biol Ther. 2010. PMID: 20150762
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