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Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells.
Tomita M, Kawakami H, Uchihara JN, Okudaira T, Masuda M, Takasu N, Matsuda T, Ohta T, Tanaka Y, Ohshiro K, Mori N. Tomita M, et al. Among authors: tanaka y. Int J Cancer. 2006 Feb 1;118(3):765-72. doi: 10.1002/ijc.21389. Int J Cancer. 2006. PMID: 16106398 Free article. Retracted.
Tax is a potential molecular target for immunotherapy of adult T-cell leukemia/lymphoma.
Suzuki S, Masaki A, Ishida T, Ito A, Mori F, Sato F, Narita T, Ri M, Kusumoto S, Komatsu H, Fukumori Y, Nishikawa H, Tanaka Y, Niimi A, Inagaki H, Iida S, Ueda R. Suzuki S, et al. Among authors: tanaka y. Cancer Sci. 2012 Oct;103(10):1764-73. doi: 10.1111/j.1349-7006.2012.02371.x. Epub 2012 Aug 13. Cancer Sci. 2012. PMID: 22735080 Free PMC article.
Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity.
Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara JN, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N. Tomita M, et al. Among authors: tanaka y. Int J Cancer. 2009 Jun 1;124(11):2607-15. doi: 10.1002/ijc.24257. Int J Cancer. 2009. PMID: 19230025 Free article. Retracted.
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