Hay N - Search Results

1

Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis.

Robey RB, Hay N. Robey RB, et al. Among authors: hay n. Semin Cancer Biol. 2009 Feb;19(1):25-31. doi: 10.1016/j.semcancer.2008.11.010. Epub 2008 Dec 14. Semin Cancer Biol. 2009. PMID: 19130886 Free PMC article. Review.

2

Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt.

Robey RB, Hay N. Robey RB, et al. Among authors: hay n. Oncogene. 2006 Aug 7;25(34):4683-96. doi: 10.1038/sj.onc.1209595. Oncogene. 2006. PMID: 16892082 Review.

3

Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases.

Majewski N, Nogueira V, Robey RB, Hay N. Majewski N, et al. Among authors: hay n. Mol Cell Biol. 2004 Jan;24(2):730-40. doi: 10.1128/MCB.24.2.730-740.2004. Mol Cell Biol. 2004. PMID: 14701745 Free PMC article.

4

Mitochondrial hexokinases: guardians of the mitochondria.

Robey RB, Hay N. Robey RB, et al. Among authors: hay n. Cell Cycle. 2005 May;4(5):654-8. doi: 10.4161/cc.4.5.1678. Epub 2005 May 15. Cell Cycle. 2005. PMID: 15846094

5

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak.

Majewski N, Nogueira V, Bhaskar P, Coy PE, Skeen JE, Gottlob K, Chandel NS, Thompson CB, Robey RB, Hay N. Majewski N, et al. Among authors: hay n. Mol Cell. 2004 Dec 3;16(5):819-30. doi: 10.1016/j.molcel.2004.11.014. Mol Cell. 2004. PMID: 15574336 Free article.

6

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase.

Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB, Hay N. Gottlob K, et al. Among authors: hay n. Genes Dev. 2001 Jun 1;15(11):1406-18. doi: 10.1101/gad.889901. Genes Dev. 2001. PMID: 11390360 Free PMC article.

7

mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition.

Bhaskar PT, Nogueira V, Patra KC, Jeon SM, Park Y, Robey RB, Hay N. Bhaskar PT, et al. Among authors: hay n. Mol Cell Biol. 2009 Sep;29(18):5136-47. doi: 10.1128/MCB.01946-08. Epub 2009 Jul 20. Mol Cell Biol. 2009. PMID: 19620286 Free PMC article.

8

Increased hexokinase activity, of either ectopic or endogenous origin, protects renal epithelial cells against acute oxidant-induced cell death.

Bryson JM, Coy PE, Gottlob K, Hay N, Robey RB. Bryson JM, et al. Among authors: hay n. J Biol Chem. 2002 Mar 29;277(13):11392-400. doi: 10.1074/jbc.M110927200. Epub 2001 Dec 18. J Biol Chem. 2002. PMID: 11751868 Free article.

9

The Akt-mTOR tango and its relevance to cancer.

Hay N. Hay N. Cancer Cell. 2005 Sep;8(3):179-83. doi: 10.1016/j.ccr.2005.08.008. Cancer Cell. 2005. PMID: 16169463 Free article. Review.

10

Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer.

Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL, Jha AK, Smolen GA, Clasquin MF, Robey B, Hay N. Patra KC, et al. Among authors: hay n. Cancer Cell. 2013 Aug 12;24(2):213-228. doi: 10.1016/j.ccr.2013.06.014. Epub 2013 Aug 1. Cancer Cell. 2013. PMID: 23911236 Free PMC article.

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