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Fast on-rates allow short dwell time ligands to activate T cells.
Govern CC, Paczosa MK, Chakraborty AK, Huseby ES. Govern CC, et al. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8724-9. doi: 10.1073/pnas.1000966107. Epub 2010 Apr 26. Proc Natl Acad Sci U S A. 2010. PMID: 20421471 Free PMC article.
Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.
Hartzell C, Ksionda O, Lemmens E, Coakley K, Yang M, Dail M, Harvey RC, Govern C, Bakker J, Lenstra TL, Ammon K, Boeter A, Winter SS, Loh M, Shannon K, Chakraborty AK, Wabl M, Roose JP. Hartzell C, et al. Among authors: govern c. Sci Signal. 2013 Mar 26;6(268):ra21. doi: 10.1126/scisignal.2003848. Sci Signal. 2013. PMID: 23532335 Free PMC article.
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