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Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets.
Costes S, Vandewalle B, Tourrel-Cuzin C, Broca C, Linck N, Bertrand G, Kerr-Conte J, Portha B, Pattou F, Bockaert J, Dalle S. Costes S, et al. Among authors: vandewalle b. Diabetes. 2009 May;58(5):1105-15. doi: 10.2337/db08-0926. Epub 2009 Feb 17. Diabetes. 2009. PMID: 19223597 Free PMC article.
Glucotoxicity inhibits late steps of insulin exocytosis.
Dubois M, Vacher P, Roger B, Huyghe D, Vandewalle B, Kerr-Conte J, Pattou F, Moustaïd-Moussa N, Lang J. Dubois M, et al. Among authors: vandewalle b. Endocrinology. 2007 Apr;148(4):1605-14. doi: 10.1210/en.2006-1022. Epub 2007 Jan 4. Endocrinology. 2007. PMID: 17204559
PCSK9 is expressed in pancreatic delta-cells and does not alter insulin secretion.
Langhi C, Le May C, Gmyr V, Vandewalle B, Kerr-Conte J, Krempf M, Pattou F, Costet P, Cariou B. Langhi C, et al. Among authors: vandewalle b. Biochem Biophys Res Commun. 2009 Dec 25;390(4):1288-93. doi: 10.1016/j.bbrc.2009.10.138. Epub 2009 Oct 28. Biochem Biophys Res Commun. 2009. PMID: 19878649
Efficient gene delivery and silencing of mouse and human pancreatic islets.
Lefebvre B, Vandewalle B, Longue J, Moerman E, Lukowiak B, Gmyr V, Maedler K, Kerr-conte J, Pattou F. Lefebvre B, et al. Among authors: vandewalle b. BMC Biotechnol. 2010 Mar 30;10:28. doi: 10.1186/1472-6750-10-28. BMC Biotechnol. 2010. PMID: 20353585 Free PMC article.
94 results