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Hepatitis C virus drug resistance and immune-driven adaptations: relevance to new antiviral therapy.
Gaudieri S, Rauch A, Pfafferott K, Barnes E, Cheng W, McCaughan G, Shackel N, Jeffrey GP, Mollison L, Baker R, Furrer H, Günthard HF, Freitas E, Humphreys I, Klenerman P, Mallal S, James I, Roberts S, Nolan D, Lucas M. Gaudieri S, et al. Among authors: pfafferott k. Hepatology. 2009 Apr;49(4):1069-82. doi: 10.1002/hep.22773. Hepatology. 2009. PMID: 19263475
Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressure.
Rauch A, James I, Pfafferott K, Nolan D, Klenerman P, Cheng W, Mollison L, McCaughan G, Shackel N, Jeffrey GP, Baker R, Freitas E, Humphreys I, Furrer H, Günthard HF, Hirschel B, Mallal S, John M, Lucas M, Barnes E, Gaudieri S. Rauch A, et al. Among authors: pfafferott k. Hepatology. 2009 Oct;50(4):1017-29. doi: 10.1002/hep.23101. Hepatology. 2009. PMID: 19670417
Evidence of CD4+ T cell-mediated immune pressure on the Hepatitis C virus genome.
Lucas M, Deshpande P, James I, Rauch A, Pfafferott K, Gaylard E, Merani S, Plauzolles A, Lucas A, McDonnell W, Kalams S, Pilkinton M, Chastain C, Barnett L, Prosser A, Mallal S, Fitzmaurice K, Drummer H, Ansari MA, Pedergnana V, Barnes E, John M, Kelleher D, Klenerman P, Gaudieri S. Lucas M, et al. Among authors: pfafferott k. Sci Rep. 2018 May 8;8(1):7224. doi: 10.1038/s41598-018-25559-6. Sci Rep. 2018. PMID: 29740042 Free PMC article.
Full-length characterization of hepatitis C virus subtype 3a reveals novel hypervariable regions under positive selection during acute infection.
Humphreys I, Fleming V, Fabris P, Parker J, Schulenberg B, Brown A, Demetriou C, Gaudieri S, Pfafferott K, Lucas M, Collier J, Huang KH, Pybus OG, Klenerman P, Barnes E. Humphreys I, et al. Among authors: pfafferott k. J Virol. 2009 Nov;83(22):11456-66. doi: 10.1128/JVI.00884-09. Epub 2009 Sep 9. J Virol. 2009. PMID: 19740991 Free PMC article.
Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease.
Desmond CP, Gaudieri S, James IR, Pfafferott K, Chopra A, Lau GK, Audsley J, Day C, Chivers S, Gordon A, Revill PA, Bowden S, Ayres A, Desmond PV, Thompson AJ, Roberts SK, Locarnini SA, Mallal SA, Lewin SR. Desmond CP, et al. Among authors: pfafferott k. J Virol. 2012 Jan;86(2):1181-92. doi: 10.1128/JVI.05308-11. Epub 2011 Nov 9. J Virol. 2012. PMID: 22072755 Free PMC article.
Influence of Transmitted Virus on the Host's Immune Response: A Case Study.
Merani S, Lucas M, Deshpande P, Pfafferott K, Chopra A, Cooper D, Leary S, Luciani F, Gaudieri S. Merani S, et al. Among authors: pfafferott k. Viral Immunol. 2017 Sep;30(7):533-541. doi: 10.1089/vim.2017.0001. Epub 2017 May 22. Viral Immunol. 2017. PMID: 28530508
34 results