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In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists.
Mantell SJ, Gibson KR, Osborne SA, Maw GN, Rees H, Dodd PG, Greener B, Harbottle GW, Million WA, Poinsard C, England S, Carnell P, Betts AM, Monhemius R, Prime RL. Mantell SJ, et al. Among authors: osborne sa. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2190-4. doi: 10.1016/j.bmcl.2009.02.106. Epub 2009 Mar 3. Bioorg Med Chem Lett. 2009. PMID: 19289283
Synthesis and in vivo evaluation of bicyclic gababutins.
Blakemore DC, Bryans JS, Carnell P, Carr CL, Chessum NE, Field MJ, Kinsella N, Osborne SA, Warren AN, Williams SC. Blakemore DC, et al. Among authors: osborne sa. Bioorg Med Chem Lett. 2010 Jan 15;20(2):461-4. doi: 10.1016/j.bmcl.2009.11.118. Epub 2009 Nov 27. Bioorg Med Chem Lett. 2010. PMID: 20005103
Synthesis and in vivo evaluation of 3-substituted gababutins.
Blakemore DC, Bryans JS, Carnell P, Chessum NE, Field MJ, Kinsella N, Kinsora JK, Osborne SA, Williams SC. Blakemore DC, et al. Among authors: osborne sa. Bioorg Med Chem Lett. 2010 Jan 1;20(1):362-5. doi: 10.1016/j.bmcl.2009.10.089. Epub 2009 Oct 25. Bioorg Med Chem Lett. 2010. PMID: 19897364
Synthesis and in vivo evaluation of 3,4-disubstituted gababutins.
Blakemore DC, Bryans JS, Carnell P, Field MJ, Kinsella N, Kinsora JK, Meltzer LT, Osborne SA, Thompson LR, Williams SC. Blakemore DC, et al. Among authors: osborne sa. Bioorg Med Chem Lett. 2010 Jan 1;20(1):248-51. doi: 10.1016/j.bmcl.2009.10.121. Epub 2009 Oct 30. Bioorg Med Chem Lett. 2010. PMID: 19910190
Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).
Chapman TM, Osborne SA, Bouloc N, Large JM, Wallace C, Birchall K, Ansell KH, Jones HM, Taylor D, Clough B, Green JL, Holder AA. Chapman TM, et al. Among authors: osborne sa. Bioorg Med Chem Lett. 2013 May 15;23(10):3064-9. doi: 10.1016/j.bmcl.2013.03.017. Epub 2013 Mar 21. Bioorg Med Chem Lett. 2013. PMID: 23570789 Free PMC article.
Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues.
Large JM, Osborne SA, Smiljanic-Hurley E, Ansell KH, Jones HM, Taylor DL, Clough B, Green JL, Holder AA. Large JM, et al. Among authors: osborne sa. Bioorg Med Chem Lett. 2013 Nov 1;23(21):6019-24. doi: 10.1016/j.bmcl.2013.08.010. Epub 2013 Aug 11. Bioorg Med Chem Lett. 2013. PMID: 24035097 Free PMC article.
Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.
Large JM, Birchall K, Bouloc NS, Merritt AT, Smiljanic-Hurley E, Tsagris DJ, Wheldon MC, Ansell KH, Coombs PJ, Kettleborough CA, Whalley D, Stewart LB, Bowyer PW, Baker DA, Osborne SA. Large JM, et al. Among authors: osborne sa. Bioorg Med Chem Lett. 2019 Feb 1;29(3):509-514. doi: 10.1016/j.bmcl.2018.11.039. Epub 2018 Nov 20. Bioorg Med Chem Lett. 2019. PMID: 30553738 Free PMC article.
54 results