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Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3.
Laverny G, Penna G, Uskokovic M, Marczak S, Maehr H, Jankowski P, Ceailles C, Vouros P, Smith B, Robinson M, Reddy GS, Adorini L. Laverny G, et al. Among authors: reddy gs. J Med Chem. 2009 Apr 23;52(8):2204-13. doi: 10.1021/jm801365a. J Med Chem. 2009. PMID: 19309155
C-20 cyclopropyl vitamin D3 analogs.
Uskokovic MR, Manchand P, Marczak S, Maehr H, Jankowski P, Adorini L, Reddy GS. Uskokovic MR, et al. Among authors: reddy gs. Curr Top Med Chem. 2006;6(12):1289-96. doi: 10.2174/156802606777864962. Curr Top Med Chem. 2006. PMID: 16848742
Enhanced biological activity of 1alpha,25-dihydroxy-20-epi-vitamin D3, the C-20 epimer of 1alpha,25-dihydroxyvitamin D3, is in part due to its metabolism into stable intermediary metabolites with significant biological activity.
Siu-Caldera ML, Sekimoto H, Peleg S, Nguyen C, Kissmeyer AM, Binderup L, Weiskopf A, Vouros P, Uskoković MR, Reddy GS. Siu-Caldera ML, et al. Among authors: reddy gs. J Steroid Biochem Mol Biol. 1999 Dec 15;71(3-4):111-21. doi: 10.1016/s0960-0760(99)00130-2. J Steroid Biochem Mol Biol. 1999. PMID: 10659699
294 results