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Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.
Palavalli LH, Prickett TD, Wunderlich JR, Wei X, Burrell AS, Porter-Gill P, Davis S, Wang C, Cronin JC, Agrawal NS, Lin JC, Westbroek W, Hoogstraten-Miller S, Molinolo AA, Fetsch P, Filie AC, O'Connell MP, Banister CE, Howard JD, Buckhaults P, Weeraratna AT, Brody LC, Rosenberg SA, Samuels Y. Palavalli LH, et al. Nat Genet. 2009 May;41(5):518-20. doi: 10.1038/ng.340. Epub 2009 Mar 29. Nat Genet. 2009. PMID: 19330028 Free PMC article.
Hear the Wnt Ror: how melanoma cells adjust to changes in Wnt.
O'Connell MP, Weeraratna AT. O'Connell MP, et al. Pigment Cell Melanoma Res. 2009 Dec;22(6):724-39. doi: 10.1111/j.1755-148X.2009.00627.x. Epub 2009 Aug 25. Pigment Cell Melanoma Res. 2009. PMID: 19708915 Free PMC article. Review.
Assaying Wnt5A-mediated invasion in melanoma cells.
O'Connell MP, French AD, Leotlela PD, Weeraratna AT. O'Connell MP, et al. Methods Mol Biol. 2008;468:243-53. doi: 10.1007/978-1-59745-249-6_19. Methods Mol Biol. 2008. PMID: 19099260 Free PMC article.
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition.
Dissanayake SK, Wade M, Johnson CE, O'Connell MP, Leotlela PD, French AD, Shah KV, Hewitt KJ, Rosenthal DT, Indig FE, Jiang Y, Nickoloff BJ, Taub DD, Trent JM, Moon RT, Bittner M, Weeraratna AT. Dissanayake SK, et al. J Biol Chem. 2007 Jun 8;282(23):17259-71. doi: 10.1074/jbc.M700075200. Epub 2007 Apr 10. J Biol Chem. 2007. PMID: 17426020 Free PMC article.
sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.
Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH 3rd, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, Meeth K, Tang HY, Yin X, Wood WH 3rd, Lehrmann E, Becker KG, Flaherty KT, Frederick DT, Wargo JA, Cooper ZA, Tetzlaff MT, Hudgens C, Aird KM, Zhang R, Xu X, Liu Q, Bartlett E, Karakousis G, Eroglu Z, Lo RS, Chan M, Menzies AM, Long GV, Johnson DB, Sosman J, Schilling B, Schadendorf D, Speicher DW, Bosenberg M, Ribas A, Weeraratna AT. Kaur A, et al. Nature. 2016 Apr 14;532(7598):250-4. doi: 10.1038/nature17392. Epub 2016 Apr 4. Nature. 2016. PMID: 27042933 Free PMC article.
Wnt5A activates the calpain-mediated cleavage of filamin A.
O'Connell MP, Fiori JL, Baugher KM, Indig FE, French AD, Camilli TC, Frank BP, Earley R, Hoek KS, Hasskamp JH, Elias EG, Taub DD, Bernier M, Weeraratna AT. O'Connell MP, et al. J Invest Dermatol. 2009 Jul;129(7):1782-9. doi: 10.1038/jid.2008.433. Epub 2009 Jan 29. J Invest Dermatol. 2009. PMID: 19177143 Free PMC article.
121 results