Konkle ME - Search Results

1

Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase.

Konkle ME, Hargrove TY, Kleshchenko YY, von Kries JP, Ridenour W, Uddin MJ, Caprioli RM, Marnett LJ, Nes WD, Villalta F, Waterman MR, Lepesheva GI. Konkle ME, et al. J Med Chem. 2009 May 14;52(9):2846-53. doi: 10.1021/jm801643b. J Med Chem. 2009. PMID: 19354253 Free PMC article.

2

The Mitochondrial Protein MitoNEET as a Probe for the Allostery of Glutamate Dehydrogenase.

Nnatubeugo C, Johnson E, Gisondi S, Roland F, Geldenhuys WJ, Menze MA, Konkle ME. Nnatubeugo C, et al. Among authors: konkle me. Molecules. 2022 Nov 29;27(23):8314. doi: 10.3390/molecules27238314. Molecules. 2022. PMID: 36500407 Free PMC article.

3

Conservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics.

Konkle ME, Blobaum AL, Moth CW, Prusakiewicz JJ, Xu S, Ghebreselasie K, Akingbade D, Jacobs AT, Rouzer CA, Lybrand TP, Marnett LJ. Konkle ME, et al. Biochemistry. 2016 Jan 19;55(2):348-59. doi: 10.1021/acs.biochem.5b01222. Epub 2015 Dec 31. Biochemistry. 2016. PMID: 26704937 Free PMC article.

4

Development of a fluorescence screening assay for binding partners of the iron-sulfur mitochondrial protein mitoNEET.

Newton E, Starcovic SA, Menze M, Konkle ME, Long TE, Hazlehurst LA, Huber JD, Robart AR, Geldenhuys WJ. Newton E, et al. Among authors: konkle me. Bioorg Med Chem Lett. 2023 Jun 1;89:129310. doi: 10.1016/j.bmcl.2023.129310. Epub 2023 May 1. Bioorg Med Chem Lett. 2023. PMID: 37137430 Free PMC article.

5

Binding of thiazolidinediones to the endoplasmic reticulum protein nutrient-deprivation autophagy factor-1.

Geldenhuys WJ, Skolik R, Konkle ME, Menze MA, Long TE, Robart AR. Geldenhuys WJ, et al. Among authors: konkle me. Bioorg Med Chem Lett. 2019 Apr 1;29(7):901-904. doi: 10.1016/j.bmcl.2019.01.041. Epub 2019 Feb 1. Bioorg Med Chem Lett. 2019. PMID: 30770154 Free PMC article.

6

Identification of disulfide bond formation between MitoNEET and glutamate dehydrogenase 1.

Roberts ME, Crail JP, Laffoon MM, Fernandez WG, Menze MA, Konkle ME. Roberts ME, et al. Among authors: konkle me. Biochemistry. 2013 Dec 17;52(50):8969-71. doi: 10.1021/bi401038w. Epub 2013 Dec 4. Biochemistry. 2013. PMID: 24295216

7

Effects of pH on the Rieske protein from Thermus thermophilus: a spectroscopic and structural analysis.

Konkle ME, Muellner SK, Schwander AL, Dicus MM, Pokhrel R, Britt RD, Taylor AB, Hunsicker-Wang LM. Konkle ME, et al. Biochemistry. 2009 Oct 20;48(41):9848-57. doi: 10.1021/bi901126u. Biochemistry. 2009. PMID: 19772300

8

Chemical modification of the Rieske protein from Thermus thermophilus using diethyl pyrocarbonate modifies ligating histidine 154 and reduces the [2FE-2S] cluster.

Konkle ME, Elsenheimer KN, Hakala K, Robicheaux JC, Weintraub ST, Hunsicker-Wang LM. Konkle ME, et al. Biochemistry. 2010 Aug 31;49(34):7272-81. doi: 10.1021/bi1007904. Biochemistry. 2010. PMID: 20684561

9

The reduction rates of DEPC-modified mutant Thermus thermophilus Rieske proteins differ when there is a negative charge proximal to the cluster.

Karagas NE, Jones CN, Osborn DJ, Dzierlenga AL, Oyala P, Konkle ME, Whitney EM, David Britt R, Hunsicker-Wang LM. Karagas NE, et al. Among authors: konkle me. J Biol Inorg Chem. 2014 Oct;19(7):1121-35. doi: 10.1007/s00775-014-1167-9. Epub 2014 Jun 11. J Biol Inorg Chem. 2014. PMID: 24916128

10

Modulation of cellular energetics by galactose and pioglitazone.

Grimm D, Altamirano L, Paudel S, Welker L, Konkle ME, Chakraborty N, Menze MA. Grimm D, et al. Among authors: konkle me. Cell Tissue Res. 2017 Sep;369(3):641-646. doi: 10.1007/s00441-017-2657-1. Epub 2017 Aug 3. Cell Tissue Res. 2017. PMID: 28776185

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