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CYP51 from Trypanosoma brucei is obtusifoliol-specific.
Lepesheva GI, Nes WD, Zhou W, Hill GC, Waterman MR. Lepesheva GI, et al. Among authors: nes wd. Biochemistry. 2004 Aug 24;43(33):10789-99. doi: 10.1021/bi048967t. Biochemistry. 2004. PMID: 15311940
CYP51: A major drug target in the cytochrome P450 superfamily.
Lepesheva GI, Hargrove TY, Kleshchenko Y, Nes WD, Villalta F, Waterman MR. Lepesheva GI, et al. Among authors: nes wd. Lipids. 2008 Dec;43(12):1117-25. doi: 10.1007/s11745-008-3225-y. Epub 2008 Sep 4. Lipids. 2008. PMID: 18769951 Free PMC article.
Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.
Lepesheva GI, Park HW, Hargrove TY, Vanhollebeke B, Wawrzak Z, Harp JM, Sundaramoorthy M, Nes WD, Pays E, Chaudhuri M, Villalta F, Waterman MR. Lepesheva GI, et al. Among authors: nes wd. J Biol Chem. 2010 Jan 15;285(3):1773-80. doi: 10.1074/jbc.M109.067470. Epub 2009 Nov 18. J Biol Chem. 2010. PMID: 19923211 Free PMC article.
Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis.
Friggeri L, Hargrove TY, Wawrzak Z, Blobaum AL, Rachakonda G, Lindsley CW, Villalta F, Nes WD, Botta M, Guengerich FP, Lepesheva GI. Friggeri L, et al. Among authors: nes wd. J Med Chem. 2018 Jul 12;61(13):5679-5691. doi: 10.1021/acs.jmedchem.8b00641. Epub 2018 Jun 25. J Med Chem. 2018. PMID: 29894182 Free PMC article.
124 results