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A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.
Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, Haqq AM, Shah SH, Arlotto M, Slentz CA, Rochon J, Gallup D, Ilkayeva O, Wenner BR, Yancy WS Jr, Eisenson H, Musante G, Surwit RS, Millington DS, Butler MD, Svetkey LP. Newgard CB, et al. Among authors: stevens rd. Cell Metab. 2009 Apr;9(4):311-26. doi: 10.1016/j.cmet.2009.02.002. Cell Metab. 2009. PMID: 19356713 Free PMC article.
Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss.
Shah SH, Crosslin DR, Haynes CS, Nelson S, Turer CB, Stevens RD, Muehlbauer MJ, Wenner BR, Bain JR, Laferrère B, Gorroochurn P, Teixeira J, Brantley PJ, Stevens VJ, Hollis JF, Appel LJ, Lien LF, Batch B, Newgard CB, Svetkey LP. Shah SH, et al. Among authors: stevens rd, stevens vj. Diabetologia. 2012 Feb;55(2):321-30. doi: 10.1007/s00125-011-2356-5. Epub 2011 Nov 8. Diabetologia. 2012. PMID: 22065088 Free PMC article. Clinical Trial.
Branched-chain amino acids alter neurobehavioral function in rats.
Coppola A, Wenner BR, Ilkayeva O, Stevens RD, Maggioni M, Slotkin TA, Levin ED, Newgard CB. Coppola A, et al. Among authors: stevens rd. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E405-13. doi: 10.1152/ajpendo.00373.2012. Epub 2012 Dec 18. Am J Physiol Endocrinol Metab. 2013. PMID: 23249694 Free PMC article.
Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness.
Batch BC, Shah SH, Newgard CB, Turer CB, Haynes C, Bain JR, Muehlbauer M, Patel MJ, Stevens RD, Appel LJ, Newby LK, Svetkey LP. Batch BC, et al. Among authors: stevens rd. Metabolism. 2013 Jul;62(7):961-9. doi: 10.1016/j.metabol.2013.01.007. Epub 2013 Feb 1. Metabolism. 2013. PMID: 23375209 Free PMC article. Clinical Trial.
Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans.
Glynn EL, Piner LW, Huffman KM, Slentz CA, Elliot-Penry L, AbouAssi H, White PJ, Bain JR, Muehlbauer MJ, Ilkayeva OR, Stevens RD, Porter Starr KN, Bales CW, Volpi E, Brosnan MJ, Trimmer JK, Rolph TP, Newgard CB, Kraus WE. Glynn EL, et al. Among authors: stevens rd. Diabetologia. 2015 Oct;58(10):2324-35. doi: 10.1007/s00125-015-3705-6. Epub 2015 Aug 9. Diabetologia. 2015. PMID: 26254576 Free PMC article.
Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export.
White PJ, Lapworth AL, An J, Wang L, McGarrah RW, Stevens RD, Ilkayeva O, George T, Muehlbauer MJ, Bain JR, Trimmer JK, Brosnan MJ, Rolph TP, Newgard CB. White PJ, et al. Among authors: stevens rd. Mol Metab. 2016 Apr 22;5(7):538-551. doi: 10.1016/j.molmet.2016.04.006. eCollection 2016 Jul. Mol Metab. 2016. PMID: 27408778 Free PMC article.
Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.
White PJ, Lapworth AL, McGarrah RW, Kwee LC, Crown SB, Ilkayeva O, An J, Carson MW, Christopher BA, Ball JR, Davies MN, Kjalarsdottir L, George T, Muehlbauer MJ, Bain JR, Stevens RD, Koves TR, Muoio DM, Brozinick JT, Gimeno RE, Brosnan MJ, Rolph TP, Kraus WE, Shah SH, Newgard CB. White PJ, et al. Among authors: stevens rd. Cell Rep. 2020 Nov 10;33(6):108375. doi: 10.1016/j.celrep.2020.108375. Cell Rep. 2020. PMID: 33176135 Free PMC article.
The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain.
Lien LF, Haqq AM, Arlotto M, Slentz CA, Muehlbauer MJ, McMahon RL, Rochon J, Gallup D, Bain JR, Ilkayeva O, Wenner BR, Stevens RD, Millington DS, Muoio DM, Butler MD, Newgard CB, Svetkey LP. Lien LF, et al. Among authors: stevens rd. OMICS. 2009 Feb;13(1):21-35. doi: 10.1089/omi.2008.0035. OMICS. 2009. PMID: 19290809 Free PMC article.
367 results