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Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2'-O-(3-carboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteridine reveals an unusual binding mode.
Cody V, Pace J, Nowak J. Cody V, et al. Among authors: pace j. Acta Crystallogr D Biol Crystallogr. 2011 Oct;67(Pt 10):875-80. doi: 10.1107/S0907444911030071. Epub 2011 Sep 8. Acta Crystallogr D Biol Crystallogr. 2011. PMID: 21931219 Free PMC article.
Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine.
Cody V, Pace J, Rosowsky A. Cody V, et al. Among authors: pace j. Acta Crystallogr D Biol Crystallogr. 2008 Sep;64(Pt 9):977-84. doi: 10.1107/S0907444908022348. Epub 2008 Aug 13. Acta Crystallogr D Biol Crystallogr. 2008. PMID: 18703847 Free PMC article.
Structural analysis of Pneumocystis carinii dihydrofolate reductase complexed with NADPH and 2,4-diamino-6-[2-(5-carboxypent-1-yn-1-yl)-5-methoxybenzyl]-5-methylpyrido[2,3-d]pyrimidine.
Cody V, Pace J, Stewart E. Cody V, et al. Among authors: pace j. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Apr 1;68(Pt 4):418-23. doi: 10.1107/S1744309112008688. Epub 2012 Mar 28. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID: 22505410 Free PMC article.
532 results