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Studies on phytanoyl-CoA 2-hydroxylase and synthesis of phytanoyl-coenzyme A.
Kershaw NJ, Mukherji M, MacKinnon CH, Claridge TD, Odell B, Wierzbicki AS, Lloyd MD, Schofield CJ. Kershaw NJ, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2545-8. doi: 10.1016/s0960-894x(01)00494-2. Bioorg Med Chem Lett. 2001. PMID: 11549466
The use of dioxygen by HIF prolyl hydroxylase (PHD1).
McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ. McNeill LA, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1547-50. doi: 10.1016/s0960-894x(02)00219-6. Bioorg Med Chem Lett. 2002. PMID: 12039559
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ. Hewitson KS, et al. Among authors: schofield cj. J Biol Chem. 2002 Jul 19;277(29):26351-5. doi: 10.1074/jbc.C200273200. Epub 2002 May 31. J Biol Chem. 2002. PMID: 12042299 Free article.
Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
Schlemminger I, Mole DR, McNeill LA, Dhanda A, Hewitson KS, Tian YM, Ratcliffe PJ, Pugh CW, Schofield CJ. Schlemminger I, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1451-4. doi: 10.1016/s0960-894x(03)00149-5. Bioorg Med Chem Lett. 2003. PMID: 12668010
2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
Mole DR, Schlemminger I, McNeill LA, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ. Mole DR, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2677-80. doi: 10.1016/s0960-894x(03)00539-0. Bioorg Med Chem Lett. 2003. PMID: 12873492
OS-9: another piece in the HIF complex story.
Flashman E, McDonough MA, Schofield CJ. Flashman E, et al. Among authors: schofield cj. Mol Cell. 2005 Feb 18;17(4):472-3. doi: 10.1016/j.molcel.2005.02.001. Mol Cell. 2005. PMID: 15721249 Free article. Review.
708 results