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Page 1
Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model.
De Fusco C, Schimpl M, Börjesson U, Cheung T, Collie I, Evans L, Narasimhan P, Stubbs C, Vazquez-Chantada M, Wagner DJ, Grondine M, Sanders MG, Tentarelli S, Underwood E, Argyrou A, Smith JM, Lynch JT, Chiarparin E, Robb G, Bagal SK, Scott JS. De Fusco C, et al. J Med Chem. 2021 May 27;64(10):6814-6826. doi: 10.1021/acs.jmedchem.1c00067. Epub 2021 Apr 26. J Med Chem. 2021. PMID: 33900758 Free article.
Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.
Michaelides IN, Collie GW, Börjesson U, Vasalou C, Alkhatib O, Barlind L, Cheung T, Dale IL, Embrey KJ, Hennessy EJ, Khurana P, Koh CM, Lamb ML, Liu J, Moss TA, O'Neill DJ, Phillips C, Shaw J, Snijder A, Storer RI, Stubbs CJ, Han F, Li C, Qiao J, Sun DQ, Wang J, Wang P, Yang W. Michaelides IN, et al. Among authors: stubbs cj. J Med Chem. 2023 Jul 13;66(13):8782-8807. doi: 10.1021/acs.jmedchem.3c00401. Epub 2023 Jun 21. J Med Chem. 2023. PMID: 37343272 Free PMC article.
Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Collie GW, Michaelides IN, Embrey K, Stubbs CJ, Börjesson U, Dale IL, Snijder A, Barlind L, Song K, Khurana P, Phillips C, Storer RI. Collie GW, et al. Among authors: stubbs cj. ACS Med Chem Lett. 2020 Dec 8;12(1):162-167. doi: 10.1021/acsmedchemlett.0c00392. eCollection 2021 Jan 14. ACS Med Chem Lett. 2020. PMID: 33488978 Free PMC article.
Discovery of a selective c-MET inhibitor with a novel binding mode.
Collie GW, Barlind L, Bazzaz S, Börjesson U, Dale IL, Disch JS, Habeshian S, Jetson R, Khurana P, Madin A, Michaelides IN, Peng L, Snijder A, Stubbs CJ. Collie GW, et al. Among authors: stubbs cj. Bioorg Med Chem Lett. 2022 Nov 1;75:128948. doi: 10.1016/j.bmcl.2022.128948. Epub 2022 Aug 17. Bioorg Med Chem Lett. 2022. PMID: 35987508 Free article.
Specific inhibition of CK2α from an anchor outside the active site.
Brear P, De Fusco C, Hadje Georgiou K, Francis-Newton NJ, Stubbs CJ, Sore HF, Venkitaraman AR, Abell C, Spring DR, Hyvönen M. Brear P, et al. Among authors: stubbs cj. Chem Sci. 2016 Nov 1;7(11):6839-6845. doi: 10.1039/c6sc02335e. Epub 2016 Jul 12. Chem Sci. 2016. PMID: 28451126 Free PMC article.
Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.
Collie GW, Koh CM, O'Neill DJ, Stubbs CJ, Khurana P, Eddershaw A, Snijder A, Mauritzson F, Barlind L, Dale IL, Shaw J, Phillips C, Hennessy EJ, Cheung T, Narvaez AJ. Collie GW, et al. Among authors: stubbs cj. ACS Med Chem Lett. 2019 Aug 2;10(9):1322-1327. doi: 10.1021/acsmedchemlett.9b00276. eCollection 2019 Sep 12. ACS Med Chem Lett. 2019. PMID: 31531204 Free PMC article.
Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies.
Lawson NL, Dix CI, Scorer PW, Stubbs CJ, Wong E, Hutchinson L, McCall EJ, Schimpl M, DeVries E, Walker J, Williams GH, Hunt J, Barker C. Lawson NL, et al. Among authors: stubbs cj. Mod Pathol. 2020 Apr;33(4):518-530. doi: 10.1038/s41379-019-0372-z. Epub 2019 Sep 26. Mod Pathol. 2020. PMID: 31558782 Free PMC article.
Correction: Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies.
Lawson NL, Dix CI, Scorer PW, Stubbs CJ, Wong E, Hutchinson L, McCall EJ, Schimpl M, DeVries E, Walker J, Williams GH, Hunt J, Barker C. Lawson NL, et al. Among authors: stubbs cj. Mod Pathol. 2020 Apr;33(4):758. doi: 10.1038/s41379-019-0379-5. Mod Pathol. 2020. PMID: 31641230 Free PMC article.
48 results