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A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy.
Quijano-Rubio A, Bhuiyan AM, Yang H, Leung I, Bello E, Ali LR, Zhangxu K, Perkins J, Chun JH, Wang W, Lajoie MJ, Ravichandran R, Kuo YH, Dougan SK, Riddell SR, Spangler JB, Dougan M, Silva DA, Baker D. Quijano-Rubio A, et al. Among authors: dougan sk, dougan m. Nat Biotechnol. 2023 Apr;41(4):532-540. doi: 10.1038/s41587-022-01510-z. Epub 2022 Oct 31. Nat Biotechnol. 2023. PMID: 36316485 Free PMC article.
IFNγ is a central node of cancer immune equilibrium.
Walsh MJ, Stump CT, Kureshi R, Lenehan P, Ali LR, Dougan M, Knipe DM, Dougan SK. Walsh MJ, et al. Among authors: dougan sk, dougan m. Cell Rep. 2023 Mar 28;42(3):112219. doi: 10.1016/j.celrep.2023.112219. Epub 2023 Mar 6. Cell Rep. 2023. PMID: 36881506 Free PMC article.
G-CSF rescue of FOLFIRINOX-induced neutropenia leads to systemic immune suppression in mice and humans.
Cardot-Ruffino V, Bollenrucher N, Delius L, Wang SJ, Brais LK, Remland J, Keheler CE, Sullivan KM, Abrams TA, Biller LH, Enzinger PC, McCleary NJ, Patel AK, Rubinson DA, Schlechter B, Slater S, Yurgelun MB, Cleary JM, Perez K, Dougan M, Ng K, Wolpin BM, Singh H, Dougan SK. Cardot-Ruffino V, et al. Among authors: dougan sk, dougan m. J Immunother Cancer. 2023 Jun;11(6):e006589. doi: 10.1136/jitc-2022-006589. J Immunother Cancer. 2023. PMID: 37344102 Free PMC article.
Immune mechanisms of toxicity from checkpoint inhibitors.
Wang SJ, Dougan SK, Dougan M. Wang SJ, et al. Among authors: dougan sk, dougan m. Trends Cancer. 2023 Jul;9(7):543-553. doi: 10.1016/j.trecan.2023.04.002. Epub 2023 Apr 27. Trends Cancer. 2023. PMID: 37117135 Free article. Review.
99 results