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Page 1
Suppression of HDAC nuclear export and cardiomyocyte hypertrophy by novel irreversible inhibitors of CRM1.
Monovich L, Koch KA, Burgis R, Osimboni E, Mann T, Wall D, Gao J, Feng Y, Vega RB, Turner BA, Hood DB, Law A, Papst PJ, Koditek D, Chapo JA, Reid BG, Melvin LS, Pagratis NC, McKinsey TA. Monovich L, et al. Among authors: pagratis nc. Biochim Biophys Acta. 2009 May;1789(5):422-31. doi: 10.1016/j.bbagrm.2009.04.001. Epub 2009 May 3. Biochim Biophys Acta. 2009. PMID: 19414071
3,5-diarylazoles as novel and selective inhibitors of protein kinase D.
Gamber GG, Meredith E, Zhu Q, Yan W, Rao C, Capparelli M, Burgis R, Enyedy I, Zhang JH, Soldermann N, Beattie K, Rozhitskaya O, Koch KA, Pagratis N, Hosagrahara V, Vega RB, McKinsey TA, Monovich L. Gamber GG, et al. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1447-51. doi: 10.1016/j.bmcl.2011.01.014. Epub 2011 Jan 11. Bioorg Med Chem Lett. 2011. PMID: 21300545
Identification of orally available naphthyridine protein kinase D inhibitors.
Meredith EL, Ardayfio O, Beattie K, Dobler MR, Enyedy I, Gaul C, Hosagrahara V, Jewell C, Koch K, Lee W, Lehmann H, McKinsey TA, Miranda K, Pagratis N, Pancost M, Patnaik A, Phan D, Plato C, Qian M, Rajaraman V, Rao C, Rozhitskaya O, Ruppen T, Shi J, Siska SJ, Springer C, van Eis M, Vega RB, von Matt A, Yang L, Yoon T, Zhang JH, Zhu N, Monovich LG. Meredith EL, et al. J Med Chem. 2010 Aug 12;53(15):5400-21. doi: 10.1021/jm100075z. J Med Chem. 2010. PMID: 20684591
Identification of potent and selective amidobipyridyl inhibitors of protein kinase D.
Meredith EL, Beattie K, Burgis R, Capparelli M, Chapo J, Dipietro L, Gamber G, Enyedy I, Hood DB, Hosagrahara V, Jewell C, Koch KA, Lee W, Lemon DD, McKinsey TA, Miranda K, Pagratis N, Phan D, Plato C, Rao C, Rozhitskaya O, Soldermann N, Springer C, van Eis M, Vega RB, Yan W, Zhu Q, Monovich LG. Meredith EL, et al. J Med Chem. 2010 Aug 12;53(15):5422-38. doi: 10.1021/jm100076w. J Med Chem. 2010. PMID: 20684592
A small-molecule inhibitor of hepatitis C virus infectivity.
Bush CO, Pokrovskii MV, Saito R, Morganelli P, Canales E, Clarke MO, Lazerwith SE, Golde J, Reid BG, Babaoglu K, Pagratis N, Zhong W, Delaney WE 4th, Paulson MS, Beran RK. Bush CO, et al. Antimicrob Agents Chemother. 2014;58(1):386-96. doi: 10.1128/AAC.02083-13. Epub 2013 Oct 28. Antimicrob Agents Chemother. 2014. PMID: 24165192 Free PMC article.
Clinical targeting of HIV capsid protein with a long-acting small molecule.
Link JO, Rhee MS, Tse WC, Zheng J, Somoza JR, Rowe W, Begley R, Chiu A, Mulato A, Hansen D, Singer E, Tsai LK, Bam RA, Chou CH, Canales E, Brizgys G, Zhang JR, Li J, Graupe M, Morganelli P, Liu Q, Wu Q, Halcomb RL, Saito RD, Schroeder SD, Lazerwith SE, Bondy S, Jin D, Hung M, Novikov N, Liu X, Villaseñor AG, Cannizzaro CE, Hu EY, Anderson RL, Appleby TC, Lu B, Mwangi J, Liclican A, Niedziela-Majka A, Papalia GA, Wong MH, Leavitt SA, Xu Y, Koditek D, Stepan GJ, Yu H, Pagratis N, Clancy S, Ahmadyar S, Cai TZ, Sellers S, Wolckenhauer SA, Ling J, Callebaut C, Margot N, Ram RR, Liu YP, Hyland R, Sinclair GI, Ruane PJ, Crofoot GE, McDonald CK, Brainard DM, Lad L, Swaminathan S, Sundquist WI, Sakowicz R, Chester AE, Lee WE, Daar ES, Yant SR, Cihlar T. Link JO, et al. Nature. 2020 Aug;584(7822):614-618. doi: 10.1038/s41586-020-2443-1. Epub 2020 Jul 1. Nature. 2020. PMID: 32612233 Free PMC article. Clinical Trial.
Lipid-sensing high-throughput ApoA-I assays.
Niedziela-Majka A, Lad L, Chisholm JW, Lagpacan L, Schwartz K, Hung M, Jin D, Fung W, Brendza KM, Liu X, Pagratis N, Sakowicz R. Niedziela-Majka A, et al. J Biomol Screen. 2012 Sep;17(8):1050-61. doi: 10.1177/1087057112451923. Epub 2012 Jul 17. J Biomol Screen. 2012. PMID: 22811478
30 results