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Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13.
J Med Chem. 2009 Jun 11;52(11):3523-38. doi: 10.1021/jm801394m.
J Med Chem. 2009.
PMID: 19422229
Potent and selective 2-naphthylsulfonamide substituted hydroxamic acid inhibitors of matrix metalloproteinase-13.
Tommasi RA, Weiler S, McQuire LW, Rogel O, Chambers M, Clark K, Doughty J, Fang J, Ganu V, Grob J, Goldberg R, Goldstein R, Lavoie S, Kulathila R, Macchia W, Melton R, Springer C, Walker M, Zhang J, Zhu L, Shultz M.
Tommasi RA, et al. Among authors: macchia w.
Bioorg Med Chem Lett. 2011 Nov 1;21(21):6440-5. doi: 10.1016/j.bmcl.2011.08.087. Epub 2011 Aug 27.
Bioorg Med Chem Lett. 2011.
PMID: 21937229
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Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design.
Greenspan PD, Clark KL, Tommasi RA, Cowen SD, McQuire LW, Farley DL, van Duzer JH, Goldberg RL, Zhou H, Du Z, Fitt JJ, Coppa DE, Fang Z, Macchia W, Zhu L, Capparelli MP, Goldstein R, Wigg AM, Doughty JR, Bohacek RS, Knap AK.
Greenspan PD, et al. Among authors: macchia w.
J Med Chem. 2001 Dec 20;44(26):4524-34. doi: 10.1021/jm010206q.
J Med Chem. 2001.
PMID: 11741472
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Angiotensin converting enzyme inhibitors: N-substituted monocyclic and bicyclic amino acid derivatives.
Stanton JL, Gruenfeld N, Babiarz JE, Ackerman MH, Friedmann RC, Yuan AM, Macchia W.
Stanton JL, et al. Among authors: macchia w.
J Med Chem. 1983 Sep;26(9):1267-77. doi: 10.1021/jm00363a011.
J Med Chem. 1983.
PMID: 6310112
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Leukotriene biosynthesis inhibition by aryl and aroyl substituted naphthoquinones.
Roland DM, Macchia WM, Grim KS, Kimble EF, White DH, Kowalski TJ.
Roland DM, et al. Among authors: macchia wm.
Agents Actions. 1991 Sep;34(1-2):145-7. doi: 10.1007/BF01993262.
Agents Actions. 1991.
PMID: 1665288
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Licensure.
Macchia WJ.
Macchia WJ.
J Am Dent Assoc. 1992 Jul;123(7):18. doi: 10.14219/jada.archive.1992.0145.
J Am Dent Assoc. 1992.
PMID: 1619158
No abstract available.
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