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Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13.
J Med Chem. 2009 Jun 11;52(11):3523-38. doi: 10.1021/jm801394m.
J Med Chem. 2009.
PMID: 19422229
N-arylaminonitriles as bioavailable peptidomimetic inhibitors of cathepsin B.
Greenspan PD, Clark KL, Cowen SD, McQuire LW, Tommasi RA, Farley DL, Quadros E, Coppa DE, Du Z, Fang Z, Zhou H, Doughty J, Toscano KT, Wigg AM, Zhou S.
Greenspan PD, et al. Among authors: mcquire lw.
Bioorg Med Chem Lett. 2003 Nov 17;13(22):4121-4. doi: 10.1016/j.bmcl.2003.08.006.
Bioorg Med Chem Lett. 2003.
PMID: 14592520
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Potent and selective 2-naphthylsulfonamide substituted hydroxamic acid inhibitors of matrix metalloproteinase-13.
Tommasi RA, Weiler S, McQuire LW, Rogel O, Chambers M, Clark K, Doughty J, Fang J, Ganu V, Grob J, Goldberg R, Goldstein R, Lavoie S, Kulathila R, Macchia W, Melton R, Springer C, Walker M, Zhang J, Zhu L, Shultz M.
Tommasi RA, et al. Among authors: mcquire lw.
Bioorg Med Chem Lett. 2011 Nov 1;21(21):6440-5. doi: 10.1016/j.bmcl.2011.08.087. Epub 2011 Aug 27.
Bioorg Med Chem Lett. 2011.
PMID: 21937229
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Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design.
Greenspan PD, Clark KL, Tommasi RA, Cowen SD, McQuire LW, Farley DL, van Duzer JH, Goldberg RL, Zhou H, Du Z, Fitt JJ, Coppa DE, Fang Z, Macchia W, Zhu L, Capparelli MP, Goldstein R, Wigg AM, Doughty JR, Bohacek RS, Knap AK.
Greenspan PD, et al. Among authors: mcquire lw.
J Med Chem. 2001 Dec 20;44(26):4524-34. doi: 10.1021/jm010206q.
J Med Chem. 2001.
PMID: 11741472
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Discovery of diamide compounds as diacylglycerol acyltransferase 1 (DGAT1) inhibitors.
Nakajima K, April M, Brewer JT, Daniels T, Forster CJ, Gilmore TA, Jain M, Kanter A, Kwak Y, Li J, McQuire L, Serrano-Wu MH, Streeper R, Szklennik P, Thompson J, Wang B.
Nakajima K, et al.
Bioorg Med Chem Lett. 2016 Feb 15;26(4):1245-8. doi: 10.1016/j.bmcl.2016.01.025. Epub 2016 Jan 11.
Bioorg Med Chem Lett. 2016.
PMID: 26804232
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The biochemical and pharmacological activity of 9-benzyl-9-deazaguanine, a potent purine nucleoside phosphorylase (PNP) inhibitor.
Kimble E, Hadala J, Ludewig R, Peters P, Greenberg G, Xiao G, Guida W, McQuire L, Simon P.
Kimble E, et al.
Inflamm Res. 1995 Aug;44 Suppl 2:S181-2. doi: 10.1007/BF01778321.
Inflamm Res. 1995.
PMID: 8548387
No abstract available.
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