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Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13.
Monovich LG, Tommasi RA, Fujimoto RA, Blancuzzi V, Clark K, Cornell WD, Doti R, Doughty J, Fang J, Farley D, Fitt J, Ganu V, Goldberg R, Goldstein R, Lavoie S, Kulathila R, Macchia W, Parker DT, Melton R, O'Byrne E, Pastor G, Pellas T, Quadros E, Reel N, Roland DM, Sakane Y, Singh H, Skiles J, Somers J, Toscano K, Wigg A, Zhou S, Zhu L, Shieh WC, Xue S, McQuire LW. Monovich LG, et al. Among authors: pastor g. J Med Chem. 2009 Jun 11;52(11):3523-38. doi: 10.1021/jm801394m. J Med Chem. 2009. PMID: 19422229
Novel C5a receptor antagonists regulate neutrophil functions in vitro and in vivo.
Pellas TC, Boyar W, van Oostrum J, Wasvary J, Fryer LR, Pastor G, Sills M, Braunwalder A, Yarwood DR, Kramer R, Kimble E, Hadala J, Haston W, Moreira-Ludewig R, Uziel-Fusi S, Peters P, Bill K, Wennogle LP. Pellas TC, et al. Among authors: pastor g. J Immunol. 1998 Jun 1;160(11):5616-21. J Immunol. 1998. PMID: 9605167
CGS 22745: a selective orally active inhibitor of 5-lipoxygenase.
Kimble E, Kowalski T, White D, Raychauduri A, Pastor G, Chertock H, Lee W, Neale R, Hamdan A, Wasley J. Kimble E, et al. Among authors: pastor g. Agents Actions. 1991 Sep;34(1-2):125-8. doi: 10.1007/BF01993256. Agents Actions. 1991. PMID: 1665286
94 results