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Mitochondrial DNA variants of respiratory complex I that uniquely characterize haplogroup T2 are associated with increased risk of age-related macular degeneration.
SanGiovanni JP, Arking DE, Iyengar SK, Elashoff M, Clemons TE, Reed GF, Henning AK, Sivakumaran TA, Xu X, DeWan A, Agrón E, Rochtchina E, Sue CM, Wang JJ, Mitchell P, Hoh J, Francis PJ, Klein ML, Chew EY, Chakravarti A. SanGiovanni JP, et al. Among authors: klein ml. PLoS One. 2009;4(5):e5508. doi: 10.1371/journal.pone.0005508. Epub 2009 May 12. PLoS One. 2009. PMID: 19434233 Free PMC article.
A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration.
Sivakumaran TA, Igo RP Jr, Kidd JM, Itsara A, Kopplin LJ, Chen W, Hagstrom SA, Peachey NS, Francis PJ, Klein ML, Chew EY, Ramprasad VL, Tay WT, Mitchell P, Seielstad M, Stambolian DE, Edwards AO, Lee KE, Leontiev DV, Jun G, Wang Y, Tian L, Qiu F, Henning AK, LaFramboise T, Sen P, Aarthi M, George R, Raman R, Das MK, Vijaya L, Kumaramanickavel G, Wong TY, Swaroop A, Abecasis GR, Klein R, Klein BE, Nickerson DA, Eichler EE, Iyengar SK. Sivakumaran TA, et al. Among authors: klein ml, klein be, klein r. PLoS One. 2011;6(10):e25598. doi: 10.1371/journal.pone.0025598. Epub 2011 Oct 12. PLoS One. 2011. PMID: 22022419 Free PMC article.
Natural history of drusenoid pigment epithelial detachment in age-related macular degeneration: Age-Related Eye Disease Study Report No. 28.
Cukras C, Agrón E, Klein ML, Ferris FL 3rd, Chew EY, Gensler G, Wong WT; Age-Related Eye Disease Study Research Group. Cukras C, et al. Among authors: klein ml. Ophthalmology. 2010 Mar;117(3):489-99. doi: 10.1016/j.ophtha.2009.12.002. Epub 2010 Jan 15. Ophthalmology. 2010. PMID: 20079925 Free PMC article. Clinical Trial.
Hypomethylation of the IL17RC promoter associates with age-related macular degeneration.
Wei L, Liu B, Tuo J, Shen D, Chen P, Li Z, Liu X, Ni J, Dagur P, Sen HN, Jawad S, Ling D, Park S, Chakrabarty S, Meyerle C, Agron E, Ferris FL 3rd, Chew EY, McCoy JP, Blum E, Francis PJ, Klein ML, Guymer RH, Baird PN, Chan CC, Nussenblatt RB. Wei L, et al. Among authors: klein ml. Cell Rep. 2012 Nov 29;2(5):1151-8. doi: 10.1016/j.celrep.2012.10.013. Epub 2012 Nov 21. Cell Rep. 2012. PMID: 23177625 Free PMC article.
510 results