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Discovery of N-{N-[(3-cyanophenyl)sulfonyl]-4(R)-cyclobutylamino-(L)-prolyl}-4-[(3',5'-dichloroisonicotinoyl) amino]-(L)-phenylalanine (MK-0668), an extremely potent and orally active antagonist of very late antigen-4.
J Med Chem. 2009 Jun 11;52(11):3449-52. doi: 10.1021/jm900257b.
J Med Chem. 2009.
PMID: 19441819
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