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Alpha-helix targeting reduces amyloid-beta peptide toxicity.
Nerelius C, Sandegren A, Sargsyan H, Raunak R, Leijonmarck H, Chatterjee U, Fisahn A, Imarisio S, Lomas DA, Crowther DC, Strömberg R, Johansson J. Nerelius C, et al. Among authors: fisahn a. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9191-6. doi: 10.1073/pnas.0810364106. Epub 2009 May 20. Proc Natl Acad Sci U S A. 2009. PMID: 19458258 Free PMC article.
Amyloid-β-induced action potential desynchronization and degradation of hippocampal gamma oscillations is prevented by interference with peptide conformation change and aggregation.
Kurudenkandy FR, Zilberter M, Biverstål H, Presto J, Honcharenko D, Strömberg R, Johansson J, Winblad B, Fisahn A. Kurudenkandy FR, et al. Among authors: fisahn a. J Neurosci. 2014 Aug 20;34(34):11416-25. doi: 10.1523/JNEUROSCI.1195-14.2014. J Neurosci. 2014. PMID: 25143621 Free PMC article.
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers.
Cohen SIA, Arosio P, Presto J, Kurudenkandy FR, Biverstal H, Dolfe L, Dunning C, Yang X, Frohm B, Vendruscolo M, Johansson J, Dobson CM, Fisahn A, Knowles TPJ, Linse S. Cohen SIA, et al. Among authors: fisahn a. Nat Struct Mol Biol. 2015 Mar;22(3):207-213. doi: 10.1038/nsmb.2971. Epub 2015 Feb 16. Nat Struct Mol Biol. 2015. PMID: 25686087 Free PMC article.
Amyloid-β Peptide Targeting Peptidomimetics for Prevention of Neurotoxicity.
Honcharenko D, Juneja A, Roshan F, Maity J, Galán-Acosta L, Biverstål H, Hjorth E, Johansson J, Fisahn A, Nilsson L, Strömberg R. Honcharenko D, et al. Among authors: fisahn a. ACS Chem Neurosci. 2019 Mar 20;10(3):1462-1477. doi: 10.1021/acschemneuro.8b00485. Epub 2019 Feb 6. ACS Chem Neurosci. 2019. PMID: 30673220
S100A9 amyloid growth and S100A9 fibril-induced impairment of gamma oscillations in area CA3 of mouse hippocampus ex vivo is prevented by Bri2 BRICHOS.
Andrade-Talavera Y, Chen G, Pansieri J, Arroyo-García LE, Toleikis Z, Smirnovas V, Johansson J, Morozova-Roche L, Fisahn A. Andrade-Talavera Y, et al. Among authors: fisahn a. Prog Neurobiol. 2022 Dec;219:102366. doi: 10.1016/j.pneurobio.2022.102366. Epub 2022 Oct 20. Prog Neurobiol. 2022. PMID: 36273719
58 results