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Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders.
J Med Chem. 2009 Jul 9;52(13):3941-53. doi: 10.1021/jm900278w.
J Med Chem. 2009.
PMID: 19489538
Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma.
Harrison BA, Whitlock NA, Voronkov MV, Almstead ZY, Gu KJ, Mabon R, Gardyan M, Hamman BD, Allen J, Gopinathan S, McKnight B, Crist M, Zhang Y, Liu Y, Courtney LF, Key B, Zhou J, Patel N, Yates PW, Liu Q, Wilson AG, Kimball SD, Crosson CE, Rice DS, Rawlins DB.
Harrison BA, et al. Among authors: gardyan m.
J Med Chem. 2009 Nov 12;52(21):6515-8. doi: 10.1021/jm901226j.
J Med Chem. 2009.
PMID: 19831390
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4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase.
Han Q, Pabba PK, Barbosa J, Mabon R, Healy JP, Gardyan MW, Terranova KM, Brommage R, Thompson AY, Schmidt JM, Wilson AG, Xu X, Tarver JE Jr, Carson KG.
Han Q, et al. Among authors: gardyan mw.
Bioorg Med Chem Lett. 2016 Feb 15;26(4):1184-7. doi: 10.1016/j.bmcl.2016.01.038. Epub 2016 Jan 18.
Bioorg Med Chem Lett. 2016.
PMID: 26821819
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Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase.
Tarver JE Jr, Pabba PK, Barbosa J, Han Q, Gardyan MW, Brommage R, Thompson AY, Schmidt JM, Wilson AGE, He W, Lombardo VK, Carson KG.
Tarver JE Jr, et al. Among authors: gardyan mw.
Bioorg Med Chem Lett. 2016 Mar 15;26(6):1525-1528. doi: 10.1016/j.bmcl.2016.02.021. Epub 2016 Feb 10.
Bioorg Med Chem Lett. 2016.
PMID: 26897593
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Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma.
Harrison BA, Almstead ZY, Burgoon H, Gardyan M, Goodwin NC, Healy J, Liu Y, Mabon R, Marinelli B, Samala L, Zhang Y, Stouch TR, Whitlock NA, Gopinathan S, McKnight B, Wang S, Patel N, Wilson AG, Hamman BD, Rice DS, Rawlins DB.
Harrison BA, et al. Among authors: gardyan m.
ACS Med Chem Lett. 2014 Nov 24;6(1):84-8. doi: 10.1021/ml500367g. eCollection 2015 Jan 8.
ACS Med Chem Lett. 2014.
PMID: 25589936
Free PMC article.
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Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of betaII tryptase.
Levell J, Astles P, Eastwood P, Cairns J, Houille O, Aldous S, Merriman G, Whiteley B, Pribish J, Czekaj M, Liang G, Maignan S, Guilloteau JP, Dupuy A, Davidson J, Harrison T, Morley A, Watson S, Fenton G, McCarthy C, Romano J, Mathew R, Engers D, Gardyan M, Sides K, Kwong J, Tsay J, Rebello S, Shen L, Wang J, Luo Y, Giardino O, Lim HK, Smith K, Pauls H.
Levell J, et al. Among authors: gardyan m.
Bioorg Med Chem. 2005 Apr 15;13(8):2859-72. doi: 10.1016/j.bmc.2005.02.014.
Bioorg Med Chem. 2005.
PMID: 15781396
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Polymer-supported tetrafluorophenol: a new activated resin for chemical library synthesis.
Salvino JM, Kumar NV, Orton E, Airey J, Kiesow T, Crawford K, Mathew R, Krolikowski P, Drew M, Engers D, Krolikowski D, Herpin T, Gardyan M, McGeehan G, Labaudiniere R.
Salvino JM, et al. Among authors: gardyan m.
J Comb Chem. 2000 Nov-Dec;2(6):691-7. doi: 10.1021/cc0000491.
J Comb Chem. 2000.
PMID: 11126297
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