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Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders.
Bagdanoff JT, Donoviel MS, Nouraldeen A, Tarver J, Fu Q, Carlsen M, Jessop TC, Zhang H, Hazelwood J, Nguyen H, Baugh SD, Gardyan M, Terranova KM, Barbosa J, Yan J, Bednarz M, Layek S, Courtney LF, Taylor J, Digeorge-Foushee AM, Gopinathan S, Bruce D, Smith T, Moran L, O'Neill E, Kramer J, Lai Z, Kimball SD, Liu Q, Sun W, Yu S, Swaffield J, Wilson A, Main A, Carson KG, Oravecz T, Augeri DJ. Bagdanoff JT, et al. Among authors: moran l. J Med Chem. 2009 Jul 9;52(13):3941-53. doi: 10.1021/jm900278w. J Med Chem. 2009. PMID: 19489538
Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932).
Bagdanoff JT, Donoviel MS, Nouraldeen A, Carlsen M, Jessop TC, Tarver J, Aleem S, Dong L, Zhang H, Boteju L, Hazelwood J, Yan J, Bednarz M, Layek S, Owusu IB, Gopinathan S, Moran L, Lai Z, Kramer J, Kimball SD, Yalamanchili P, Heydorn WE, Frazier KS, Brooks B, Brown P, Wilson A, Sonnenburg WK, Main A, Carson KG, Oravecz T, Augeri DJ. Bagdanoff JT, et al. Among authors: moran l. J Med Chem. 2010 Dec 23;53(24):8650-62. doi: 10.1021/jm101183p. Epub 2010 Nov 22. J Med Chem. 2010. PMID: 21090716 Clinical Trial.
Thiols in cellular redox signalling and control.
Moran LK, Gutteridge JM, Quinlan GJ. Moran LK, et al. Curr Med Chem. 2001 Jun;8(7):763-72. doi: 10.2174/0929867013372904. Curr Med Chem. 2001. PMID: 11375748 Review.
Dopamine clearance in critically ill patients.
Juste RN, Moran L, Hooper J, Soni N. Juste RN, et al. Among authors: moran l. Intensive Care Med. 1998 Nov;24(11):1217-20. doi: 10.1007/s001340050747. Intensive Care Med. 1998. PMID: 9876986
Hypocholesterolaemia in a hospital population.
Crook MA, Velauthar U, Moran L, Griffiths W. Crook MA, et al. Among authors: moran l. Ann Clin Biochem. 1999 Sep;36 ( Pt 5):613-6. doi: 10.1177/000456329903600508. Ann Clin Biochem. 1999. PMID: 10505211
769 results