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Suppression of human immunodeficiency virus type 1 (HIV-1) viremia with reverse transcriptase and integrase inhibitors, CD4+ T-cell recovery, and viral rebound upon interruption of therapy in a new model for HIV treatment in the humanized Rag2-/-{gamma}c-/- mouse.
Choudhary SK, Rezk NL, Ince WL, Cheema M, Zhang L, Su L, Swanstrom R, Kashuba AD, Margolis DM. Choudhary SK, et al. J Virol. 2009 Aug;83(16):8254-8. doi: 10.1128/JVI.00580-09. Epub 2009 Jun 3. J Virol. 2009. PMID: 19494021 Free PMC article.
Curing HIV: Pharmacologic approaches to target HIV-1 latency.
Choudhary SK, Margolis DM. Choudhary SK, et al. Annu Rev Pharmacol Toxicol. 2011;51:397-418. doi: 10.1146/annurev-pharmtox-010510-100237. Annu Rev Pharmacol Toxicol. 2011. PMID: 21210747 Free PMC article. Review.
Generation of HIV latency in humanized BLT mice.
Denton PW, Olesen R, Choudhary SK, Archin NM, Wahl A, Swanson MD, Chateau M, Nochi T, Krisko JF, Spagnuolo RA, Margolis DM, Garcia JV. Denton PW, et al. Among authors: choudhary sk. J Virol. 2012 Jan;86(1):630-4. doi: 10.1128/JVI.06120-11. Epub 2011 Oct 19. J Virol. 2012. PMID: 22013053 Free PMC article.
Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy.
Archin NM, Liberty AL, Kashuba AD, Choudhary SK, Kuruc JD, Crooks AM, Parker DC, Anderson EM, Kearney MF, Strain MC, Richman DD, Hudgens MG, Bosch RJ, Coffin JM, Eron JJ, Hazuda DJ, Margolis DM. Archin NM, et al. Among authors: choudhary sk. Nature. 2012 Jul 25;487(7408):482-5. doi: 10.1038/nature11286. Nature. 2012. PMID: 22837004 Free PMC article.
Targeted cytotoxic therapy kills persisting HIV infected cells during ART.
Denton PW, Long JM, Wietgrefe SW, Sykes C, Spagnuolo RA, Snyder OD, Perkey K, Archin NM, Choudhary SK, Yang K, Hudgens MG, Pastan I, Haase AT, Kashuba AD, Berger EA, Margolis DM, Garcia JV. Denton PW, et al. Among authors: choudhary sk. PLoS Pathog. 2014 Jan;10(1):e1003872. doi: 10.1371/journal.ppat.1003872. Epub 2014 Jan 9. PLoS Pathog. 2014. PMID: 24415939 Free PMC article.
330 results