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Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols.
Parmar MK, Sydes MR, Cafferty FH, Choodari-Oskooei B, Langley RE, Brown L, Phillips PP, Spears MR, Rowley S, Kaplan R, James ND, Maughan T, Paton N, Royston PJ. Parmar MK, et al. Clin Trials. 2017 Oct;14(5):451-461. doi: 10.1177/1740774517725697. Epub 2017 Aug 22. Clin Trials. 2017. PMID: 28830236 Free PMC article.
Speeding up the evaluation of new agents in cancer.
Parmar MK, Barthel FM, Sydes M, Langley R, Kaplan R, Eisenhauer E, Brady M, James N, Bookman MA, Swart AM, Qian W, Royston P. Parmar MK, et al. Among authors: royston p. J Natl Cancer Inst. 2008 Sep 3;100(17):1204-14. doi: 10.1093/jnci/djn267. Epub 2008 Aug 26. J Natl Cancer Inst. 2008. PMID: 18728279 Free PMC article.
Combined test versus logrank/Cox test in 50 randomised trials.
Royston P, Choodari-Oskooei B, Parmar MKB, Rogers JK. Royston P, et al. Trials. 2019 Mar 18;20(1):172. doi: 10.1186/s13063-019-3251-5. Trials. 2019. PMID: 30885277 Free PMC article.
We compared the results from the logrank/Cox test with those from the combined test recently proposed by Royston and Parmar. RESULTS: The PH assumption was checked and reported only in 28% of the studies. ...In four of five trials with discordant results, the interpretatio …
We compared the results from the logrank/Cox test with those from the combined test recently proposed by Royston and Parmar. RESULTS: …
185 results