Tang W - Search Results

1

Utility of unbound plasma drug levels and P-glycoprotein transport data in prediction of central nervous system exposure.

He H, Lyons KA, Shen X, Yao Z, Bleasby K, Chan G, Hafey M, Li X, Xu S, Salituro GM, Cohen LH, Tang W. He H, et al. Among authors: tang w. Xenobiotica. 2009 Sep;39(9):687-93. doi: 10.1080/00498250903015402. Xenobiotica. 2009. PMID: 19569734

2

Importance of mechanistic drug metabolism studies in support of drug discovery: A case study with an N -sulfonylated dipeptide VLA-4 antagonist in rats.

Tang W, Stearns RA, Chen Q, Bleasby K, Teffera Y, Colletti A, Hafey M, Evers R, Dean DC, Magriotis PA, Lanza TJ, Lin LS, Hagmann WK, Baillie TA. Tang W, et al. Xenobiotica. 2008 Feb;38(2):223-37. doi: 10.1080/00498250701744682. Xenobiotica. 2008. PMID: 18197560

3

Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: a case study with melanocortin-4 receptor agonists.

Tang W, Stearns RA, Wang RW, Miller RR, Chen Q, Ngui J, Bakshi RK, Nargund RP, Dean DC, Baillie TA. Tang W, et al. Xenobiotica. 2008 Nov;38(11):1437-51. doi: 10.1080/00498250802464685. Xenobiotica. 2008. PMID: 18841517

4

Influence of different recombinant systems on the cooperativity exhibited by cytochrome P4503A4.

Zhang Z, Li Y, Shou M, Zhang Y, Ngui JS, Stearns RA, Evans DC, Baillie TA, Tang W. Zhang Z, et al. Among authors: tang w. Xenobiotica. 2004 May;34(5):473-86. doi: 10.1080/00498250410001691271. Xenobiotica. 2004. PMID: 15370963

5

Effect of the anticoagulant ethylenediamine tetra-acetic acid (EDTA) on the estimation of pharmacokinetic parameters: A case study with tigecycline and ciprofloxacin.

Chen Q, Tung EC, Ciccotto SL, Strauss JR, Ortiga R, Ramsay KA, Tang W. Chen Q, et al. Among authors: tang w. Xenobiotica. 2008 Jan;38(1):76-86. doi: 10.1080/00498250701678955. Xenobiotica. 2008. PMID: 17963190

6

Recent advances in P-glycoprotein-mediated multidrug resistance reversal mechanisms.

Li X, Li JP, Yuan HY, Gao X, Qu XJ, Xu WF, Tang W. Li X, et al. Among authors: tang w. Methods Find Exp Clin Pharmacol. 2007 Nov;29(9):607-17. doi: 10.1358/mf.2007.29.9.1139054. Methods Find Exp Clin Pharmacol. 2007. PMID: 18193112 Free article. Review.

7

Attenuating pregnane X receptor (PXR) activation: a molecular modelling approach.

Gao YD, Olson SH, Balkovec JM, Zhu Y, Royo I, Yabut J, Evers R, Tan EY, Tang W, Hartley DP, Mosley RT. Gao YD, et al. Among authors: tang w. Xenobiotica. 2007 Feb;37(2):124-38. doi: 10.1080/00498250601050412. Xenobiotica. 2007. PMID: 17484516

8

Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.

Hoyt SB, Taylor J, London C, Ali A, Ujjainwalla F, Tata J, Struthers M, Cully D, Wisniewski T, Ren N, Bopp C, Sok A, Verras A, McMasters D, Chen Q, Tung E, Tang W, Salituro G, Clemas J, Zhou G, MacNeil D, Duffy R, Xiong Y. Hoyt SB, et al. Among authors: tang w. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2384-2388. doi: 10.1016/j.bmcl.2017.04.021. Epub 2017 Apr 8. Bioorg Med Chem Lett. 2017. PMID: 28416132

9

In vitro metabolic activation of lumiracoxib in rat and human liver preparations.

Li Y, Slatter JG, Zhang Z, Li Y, Doss GA, Braun MP, Stearns RA, Dean DC, Baillie TA, Tang W. Li Y, et al. Among authors: tang w. Drug Metab Dispos. 2008 Feb;36(2):469-73. doi: 10.1124/dmd.107.019018. Epub 2007 Nov 12. Drug Metab Dispos. 2008. PMID: 17998295

10

Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension.

Petrilli WL, Hoyt SB, London C, McMasters D, Verras A, Struthers M, Cully D, Wisniewski T, Ren N, Bopp C, Sok A, Chen Q, Li Y, Tung E, Tang W, Salituro G, Knemeyer I, Karanam B, Clemas J, Zhou G, Gibson J, Shipley CA, MacNeil DJ, Duffy R, Tata JR, Ujjainwalla F, Ali A, Xiong Y. Petrilli WL, et al. Among authors: tang w. ACS Med Chem Lett. 2016 Nov 22;8(1):128-132. doi: 10.1021/acsmedchemlett.6b00455. eCollection 2017 Jan 12. ACS Med Chem Lett. 2016. PMID: 28105288 Free PMC article.

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