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A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.
Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH. Day JW, et al. Among authors: abplanalp w. Nat Chem Biol. 2009 Oct;5(10):749-57. doi: 10.1038/nchembio.209. Epub 2009 Jul 13. Nat Chem Biol. 2009. PMID: 19597507
The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.
Müller TD, Müller A, Yi CX, Habegger KM, Meyer CW, Gaylinn BD, Finan B, Heppner K, Trivedi C, Bielohuby M, Abplanalp W, Meyer F, Piechowski CL, Pratzka J, Stemmer K, Holland J, Hembree J, Bhardwaj N, Raver C, Ottaway N, Krishna R, Sah R, Sallee FR, Woods SC, Perez-Tilve D, Bidlingmaier M, Thorner MO, Krude H, Smiley D, DiMarchi R, Hofmann S, Pfluger PT, Kleinau G, Biebermann H, Tschöp MH. Müller TD, et al. Among authors: abplanalp w. Nat Commun. 2013;4:1968. doi: 10.1038/ncomms2968. Nat Commun. 2013. PMID: 23744028 Free PMC article.
Caloric restriction chronically impairs metabolic programming in mice.
Kirchner H, Hofmann SM, Fischer-Rosinský A, Hembree J, Abplanalp W, Ottaway N, Donelan E, Krishna R, Woods SC, Müller TD, Spranger J, Perez-Tilve D, Pfluger PT, Tschöp MH, Habegger KM. Kirchner H, et al. Among authors: abplanalp w. Diabetes. 2012 Nov;61(11):2734-42. doi: 10.2337/db11-1621. Epub 2012 Jul 10. Diabetes. 2012. PMID: 22787140 Free PMC article.
Metabolic control by S6 kinases depends on dietary lipids.
Castañeda TR, Abplanalp W, Um SH, Pfluger PT, Schrott B, Brown K, Grant E, Carnevalli L, Benoit SC, Morgan DA, Gilham D, Hui DY, Rahmouni K, Thomas G, Kozma SC, Clegg DJ, Tschöp MH. Castañeda TR, et al. Among authors: abplanalp w. PLoS One. 2012;7(3):e32631. doi: 10.1371/journal.pone.0032631. Epub 2012 Mar 7. PLoS One. 2012. PMID: 22412899 Free PMC article.
Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling.
Stevanovic D, Trajkovic V, Müller-Lühlhoff S, Brandt E, Abplanalp W, Bumke-Vogt C, Liehl B, Wiedmer P, Janjetovic K, Starcevic V, Pfeiffer AF, Al-Hasani H, Tschöp MH, Castañeda TR. Stevanovic D, et al. Among authors: abplanalp w. Mol Cell Endocrinol. 2013 Dec 5;381(1-2):280-90. doi: 10.1016/j.mce.2013.08.009. Epub 2013 Aug 29. Mol Cell Endocrinol. 2013. PMID: 23994018
High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice.
Lehti M, Donelan E, Abplanalp W, Al-Massadi O, Habegger KM, Weber J, Ress C, Mansfeld J, Somvanshi S, Trivedi C, Keuper M, Ograjsek T, Striese C, Cucuruz S, Pfluger PT, Krishna R, Gordon SM, Silva RA, Luquet S, Castel J, Martinez S, D'Alessio D, Davidson WS, Hofmann SM. Lehti M, et al. Among authors: abplanalp w. Circulation. 2013 Nov 26;128(22):2364-71. doi: 10.1161/CIRCULATIONAHA.113.001551. Epub 2013 Oct 29. Circulation. 2013. PMID: 24170386 Free PMC article.
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents.
Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ. Benoit SC, et al. Among authors: abplanalp w. J Clin Invest. 2009 Sep;119(9):2577-89. doi: 10.1172/JCI36714. Epub 2009 Aug 10. J Clin Invest. 2009. PMID: 19726875 Free PMC article.
Modulation of phosphoinositide-protein kinase C signal transduction by omega-3 fatty acids: implications for the pathophysiology and treatment of recurrent neuropsychiatric illness.
McNamara RK, Ostrander M, Abplanalp W, Richtand NM, Benoit SC, Clegg DJ. McNamara RK, et al. Among authors: abplanalp w. Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov;75(4-5):237-57. doi: 10.1016/j.plefa.2006.07.009. Epub 2006 Aug 28. Prostaglandins Leukot Essent Fatty Acids. 2006. PMID: 16935483 Review.
64 results