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963 results

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Page 1
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.
Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH. Day JW, et al. Among authors: kirchner h. Nat Chem Biol. 2009 Oct;5(10):749-57. doi: 10.1038/nchembio.209. Epub 2009 Jul 13. Nat Chem Biol. 2009. PMID: 19597507
Acylation type determines ghrelin's effects on energy homeostasis in rodents.
Heppner KM, Chaudhary N, Müller TD, Kirchner H, Habegger KM, Ottaway N, Smiley DL, Dimarchi R, Hofmann SM, Woods SC, Sivertsen B, Holst B, Pfluger PT, Perez-Tilve D, Tschöp MH. Heppner KM, et al. Among authors: kirchner h. Endocrinology. 2012 Oct;153(10):4687-95. doi: 10.1210/en.2012-1194. Epub 2012 Aug 3. Endocrinology. 2012. PMID: 22865372 Free PMC article.
Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.
Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, DiMarchi RD, Tschöp MH. Finan B, et al. Among authors: kirchner h. Sci Transl Med. 2013 Oct 30;5(209):209ra151. doi: 10.1126/scitranslmed.3007218. Sci Transl Med. 2013. PMID: 24174327 Clinical Trial.
GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats.
Habegger KM, Kirchner H, Yi CX, Heppner KM, Sweeney D, Ottaway N, Holland J, Amburgy S, Raver C, Krishna R, Müller TD, Perez-Tilve D, Pfluger PT, Obici S, DiMarchi RD, D'Alessio DA, Seeley RJ, Tschöp MH. Habegger KM, et al. Among authors: kirchner h. Diabetes. 2013 Sep;62(9):3261-7. doi: 10.2337/db13-0117. Epub 2013 Jun 17. Diabetes. 2013. PMID: 23775764 Free PMC article.
The role of ghrelin in the control of energy balance.
Kirchner H, Heppner KM, Tschöp MH. Kirchner H, et al. Handb Exp Pharmacol. 2012;(209):161-84. doi: 10.1007/978-3-642-24716-3_7. Handb Exp Pharmacol. 2012. PMID: 22249814 Review.
Caloric restriction chronically impairs metabolic programming in mice.
Kirchner H, Hofmann SM, Fischer-Rosinský A, Hembree J, Abplanalp W, Ottaway N, Donelan E, Krishna R, Woods SC, Müller TD, Spranger J, Perez-Tilve D, Pfluger PT, Tschöp MH, Habegger KM. Kirchner H, et al. Diabetes. 2012 Nov;61(11):2734-42. doi: 10.2337/db11-1621. Epub 2012 Jul 10. Diabetes. 2012. PMID: 22787140 Free PMC article.
Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure.
Pfluger PT, Kirchner H, Günnel S, Schrott B, Perez-Tilve D, Fu S, Benoit SC, Horvath T, Joost HG, Wortley KE, Sleeman MW, Tschöp MH. Pfluger PT, et al. Among authors: kirchner h. Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G610-8. doi: 10.1152/ajpgi.00321.2007. Epub 2007 Nov 29. Am J Physiol Gastrointest Liver Physiol. 2008. PMID: 18048479 Free article.
Ghrelin-induced adiposity is independent of orexigenic effects.
Perez-Tilve D, Heppner K, Kirchner H, Lockie SH, Woods SC, Smiley DL, Tschöp M, Pfluger P. Perez-Tilve D, et al. Among authors: kirchner h. FASEB J. 2011 Aug;25(8):2814-22. doi: 10.1096/fj.11-183632. Epub 2011 May 4. FASEB J. 2011. PMID: 21543764 Free PMC article.
The effects of vertical sleeve gastrectomy in rodents are ghrelin independent.
Chambers AP, Kirchner H, Wilson-Perez HE, Willency JA, Hale JE, Gaylinn BD, Thorner MO, Pfluger PT, Gutierrez JA, Tschöp MH, Sandoval DA, Seeley RJ. Chambers AP, et al. Among authors: kirchner h. Gastroenterology. 2013 Jan;144(1):50-52.e5. doi: 10.1053/j.gastro.2012.09.009. Epub 2012 Sep 17. Gastroenterology. 2013. PMID: 22995675 Free PMC article.
963 results