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A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.
Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH. Day JW, et al. Among authors: patterson jt. Nat Chem Biol. 2009 Oct;5(10):749-57. doi: 10.1038/nchembio.209. Epub 2009 Jul 13. Nat Chem Biol. 2009. PMID: 19597507
Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity.
Nogueiras R, Pérez-Tilve D, Veyrat-Durebex C, Morgan DA, Varela L, Haynes WG, Patterson JT, Disse E, Pfluger PT, López M, Woods SC, DiMarchi R, Diéguez C, Rahmouni K, Rohner-Jeanrenaud F, Tschöp MH. Nogueiras R, et al. Among authors: patterson jt. J Neurosci. 2009 May 6;29(18):5916-25. doi: 10.1523/JNEUROSCI.5977-08.2009. J Neurosci. 2009. PMID: 19420258 Free PMC article.
Melanocortin signaling in the CNS directly regulates circulating cholesterol.
Perez-Tilve D, Hofmann SM, Basford J, Nogueiras R, Pfluger PT, Patterson JT, Grant E, Wilson-Perez HE, Granholm NA, Arnold M, Trevaskis JL, Butler AA, Davidson WS, Woods SC, Benoit SC, Sleeman MW, DiMarchi RD, Hui DY, Tschöp MH. Perez-Tilve D, et al. Among authors: patterson jt. Nat Neurosci. 2010 Jul;13(7):877-82. doi: 10.1038/nn.2569. Epub 2010 Jun 6. Nat Neurosci. 2010. PMID: 20526334 Free PMC article.
Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic β-cells.
Kuna RS, Girada SB, Asalla S, Vallentyne J, Maddika S, Patterson JT, Smiley DL, DiMarchi RD, Mitra P. Kuna RS, et al. Among authors: patterson jt. Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E161-70. doi: 10.1152/ajpendo.00551.2012. Epub 2013 Apr 16. Am J Physiol Endocrinol Metab. 2013. PMID: 23592482 Free article.
Subchondral rafting wires reduce tibial plateau fracture subsidence.
Patterson JT, Rusu D, Duong AM, Satish V, Yang M, Mayer L, Allen M, Marecek GS. Patterson JT, et al. Eur J Orthop Surg Traumatol. 2024 May 9. doi: 10.1007/s00590-024-03963-1. Online ahead of print. Eur J Orthop Surg Traumatol. 2024. PMID: 38720055
187 results