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A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.
Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH. Day JW, et al. Nat Chem Biol. 2009 Oct;5(10):749-57. doi: 10.1038/nchembio.209. Epub 2009 Jul 13. Nat Chem Biol. 2009. PMID: 19597507
Ghrelin action in the brain controls adipocyte metabolism.
Theander-Carrillo C, Wiedmer P, Cettour-Rose P, Nogueiras R, Perez-Tilve D, Pfluger P, Castaneda TR, Muzzin P, Schürmann A, Szanto I, Tschöp MH, Rohner-Jeanrenaud F. Theander-Carrillo C, et al. J Clin Invest. 2006 Jul;116(7):1983-93. doi: 10.1172/JCI25811. Epub 2006 Jun 8. J Clin Invest. 2006. PMID: 16767221 Free PMC article.
Effects of obestatin on energy balance and growth hormone secretion in rodents.
Nogueiras R, Pfluger P, Tovar S, Arnold M, Mitchell S, Morris A, Perez-Tilve D, Vázquez MJ, Wiedmer P, Castañeda TR, DiMarchi R, Tschöp M, Schurmann A, Joost HG, Williams LM, Langhans W, Diéguez C. Nogueiras R, et al. Endocrinology. 2007 Jan;148(1):21-6. doi: 10.1210/en.2006-0915. Epub 2006 Sep 28. Endocrinology. 2007. PMID: 17008393
The central melanocortin system directly controls peripheral lipid metabolism.
Nogueiras R, Wiedmer P, Perez-Tilve D, Veyrat-Durebex C, Keogh JM, Sutton GM, Pfluger PT, Castaneda TR, Neschen S, Hofmann SM, Howles PN, Morgan DA, Benoit SC, Szanto I, Schrott B, Schürmann A, Joost HG, Hammond C, Hui DY, Woods SC, Rahmouni K, Butler AA, Farooqi IS, O'Rahilly S, Rohner-Jeanrenaud F, Tschöp MH. Nogueiras R, et al. J Clin Invest. 2007 Nov;117(11):3475-88. doi: 10.1172/JCI31743. J Clin Invest. 2007. PMID: 17885689 Free PMC article.
114 results