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312 results

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Page 1
Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.
Shuldiner AR, O'Connell JR, Bliden KP, Gandhi A, Ryan K, Horenstein RB, Damcott CM, Pakyz R, Tantry US, Gibson Q, Pollin TI, Post W, Parsa A, Mitchell BD, Faraday N, Herzog W, Gurbel PA. Shuldiner AR, et al. Among authors: gibson q. JAMA. 2009 Aug 26;302(8):849-57. doi: 10.1001/jama.2009.1232. JAMA. 2009. PMID: 19706858 Free PMC article.
Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response.
Lewis JP, Fisch AS, Ryan K, O'Connell JR, Gibson Q, Mitchell BD, Shen H, Tanner K, Horenstein RB, Pakzy R, Tantry US, Bliden KP, Gurbel PA, Shuldiner AR. Lewis JP, et al. Among authors: gibson q. Clin Pharmacol Ther. 2011 Oct;90(4):568-74. doi: 10.1038/clpt.2011.194. Epub 2011 Aug 31. Clin Pharmacol Ther. 2011. PMID: 21881565 Free PMC article. Clinical Trial.
Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels.
Cheng YC, Kao WH, Mitchell BD, O'Connell JR, Shen H, McArdle PF, Gibson Q, Ryan KA, Shuldiner AR, Pollin TI. Cheng YC, et al. Among authors: gibson q. Circ Cardiovasc Genet. 2009 Aug;2(4):329-37. doi: 10.1161/CIRCGENETICS.108.834986. Epub 2009 May 14. Circ Cardiovasc Genet. 2009. PMID: 20031604 Free PMC article.
The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response.
Lewis JP, Horenstein RB, Ryan K, O'Connell JR, Gibson Q, Mitchell BD, Tanner K, Chai S, Bliden KP, Tantry US, Peer CJ, Figg WD, Spencer SD, Pacanowski MA, Gurbel PA, Shuldiner AR. Lewis JP, et al. Among authors: gibson q. Pharmacogenet Genomics. 2013 Jan;23(1):1-8. doi: 10.1097/FPC.0b013e32835aa8a2. Pharmacogenet Genomics. 2013. PMID: 23111421 Free PMC article.
Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes.
Lewis JP, Ryan K, O'Connell JR, Horenstein RB, Damcott CM, Gibson Q, Pollin TI, Mitchell BD, Beitelshees AL, Pakzy R, Tanner K, Parsa A, Tantry US, Bliden KP, Post WS, Faraday N, Herzog W, Gong Y, Pepine CJ, Johnson JA, Gurbel PA, Shuldiner AR. Lewis JP, et al. Among authors: gibson q. Circ Cardiovasc Genet. 2013 Apr;6(2):184-92. doi: 10.1161/CIRCGENETICS.111.964627. Epub 2013 Feb 7. Circ Cardiovasc Genet. 2013. PMID: 23392654 Free PMC article. Clinical Trial.
Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease.
Musunuru K, Post WS, Herzog W, Shen H, O'Connell JR, McArdle PF, Ryan KA, Gibson Q, Cheng YC, Clearfield E, Johnson AD, Tofler G, Yang Q, O'Donnell CJ, Becker DM, Yanek LR, Becker LC, Faraday N, Bielak LF, Peyser PA, Shuldiner AR, Mitchell BD. Musunuru K, et al. Among authors: gibson q. Circ Cardiovasc Genet. 2010 Oct;3(5):445-53. doi: 10.1161/CIRCGENETICS.109.923508. Epub 2010 Sep 21. Circ Cardiovasc Genet. 2010. PMID: 20858905 Free PMC article.
Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI Genetics of Lipid Lowering Drugs and Diet Network (GOLDN).
Wojczynski MK, Parnell LD, Pollin TI, Lai CQ, Feitosa MF, O'Connell JR, Frazier-Wood AC, Gibson Q, Aslibekyan S, Ryan KA, Province MA, Tiwari HK, Ordovas JM, Shuldiner AR, Arnett DK, Borecki IB. Wojczynski MK, et al. Among authors: gibson q. Metabolism. 2015 Oct;64(10):1359-71. doi: 10.1016/j.metabol.2015.07.001. Epub 2015 Jul 3. Metabolism. 2015. PMID: 26256467 Free PMC article.
Genome-wide association studies identified novel loci for non-high-density lipoprotein cholesterol and its postprandial lipemic response.
An P, Straka RJ, Pollin TI, Feitosa MF, Wojczynski MK, Daw EW, O'Connell JR, Gibson Q, Ryan KA, Hopkins PN, Tsai MY, Lai CQ, Province MA, Ordovas JM, Shuldiner AR, Arnett DK, Borecki IB. An P, et al. Among authors: gibson q. Hum Genet. 2014 Jul;133(7):919-30. doi: 10.1007/s00439-014-1435-3. Epub 2014 Mar 7. Hum Genet. 2014. PMID: 24604477 Free PMC article.
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Johnson AD, Bochud M, Rice KM, Henneman P, Smith AV, Ehret GB, Amin N, Larson MG, Mooser V, Hadley D, Dörr M, Bis JC, Aspelund T, Esko T, Janssens AC, Zhao JH, Heath S, Laan M, Fu J, Pistis G, Luan J, Arora P, Lucas G, Pirastu N, Pichler I, Jackson AU, Webster RJ, Zhang F, Peden JF, Schmidt H, Tanaka T, Campbell H, Igl W, Milaneschi Y, Hottenga JJ, Vitart V, Chasman DI, Trompet S, Bragg-Gresham JL, Alizadeh BZ, Chambers JC, Guo X, Lehtimäki T, Kühnel B, Lopez LM, Polašek O, Boban M, Nelson CP, Morrison AC, Pihur V, Ganesh SK, Hofman A, Kundu S, Mattace-Raso FU, Rivadeneira F, Sijbrands EJ, Uitterlinden AG, Hwang SJ, Vasan RS, Wang TJ, Bergmann S, Vollenweider P, Waeber G, Laitinen J, Pouta A, Zitting P, McArdle WL, Kroemer HK, Völker U, Völzke H, Glazer NL, Taylor KD, Harris TB, Alavere H, Haller T, Keis A, Tammesoo ML, Aulchenko Y, Barroso I, Khaw KT, Galan P, Hercberg S, Lathrop M, Eyheramendy S, Org E, Sõber S, Lu X, Nolte IM, Penninx BW, Corre T, Masciullo C, Sala C, Groop L, Voight BF, Melander O, O'Donnell CJ, Salomaa V, d'Adamo AP, Fabretto A, Faletra F, Ulivi S, Del Greco F, Facheris M, Collins FS, Bergman RN, Beilby JP,… See abstract for full author list ➔ Wain LV, et al. Nat Genet. 2011 Sep 11;43(10):1005-11. doi: 10.1038/ng.922. Nat Genet. 2011. PMID: 21909110 Free PMC article.
312 results