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S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4.
Spiekerkoetter E, Guignabert C, de Jesus Perez V, Alastalo TP, Powers JM, Wang L, Lawrie A, Ambartsumian N, Schmidt AM, Berryman M, Ashley RH, Rabinovitch M. Spiekerkoetter E, et al. Among authors: alastalo tp. Circ Res. 2009 Sep 25;105(7):639-47, 13 p following 647. doi: 10.1161/CIRCRESAHA.109.205120. Epub 2009 Aug 27. Circ Res. 2009. PMID: 19713532 Free PMC article.
Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension.
Sawada H, Saito T, Nickel NP, Alastalo TP, Glotzbach JP, Chan R, Haghighat L, Fuchs G, Januszyk M, Cao A, Lai YJ, Perez Vde J, Kim YM, Wang L, Chen PI, Spiekerkoetter E, Mitani Y, Gurtner GC, Sarnow P, Rabinovitch M. Sawada H, et al. Among authors: alastalo tp. J Exp Med. 2014 Feb 10;211(2):263-80. doi: 10.1084/jem.20111741. Epub 2014 Jan 20. J Exp Med. 2014. PMID: 24446489 Free PMC article.
Targeting the Wnt signaling pathways in pulmonary arterial hypertension.
de Jesus Perez V, Yuan K, Alastalo TP, Spiekerkoetter E, Rabinovitch M. de Jesus Perez V, et al. Among authors: alastalo tp. Drug Discov Today. 2014 Aug;19(8):1270-6. doi: 10.1016/j.drudis.2014.06.014. Epub 2014 Jun 20. Drug Discov Today. 2014. PMID: 24955837 Free PMC article. Review.
Loss of PPARγ in endothelial cells leads to impaired angiogenesis.
Vattulainen-Collanus S, Akinrinade O, Li M, Koskenvuo M, Li CG, Rao SP, de Jesus Perez V, Yuan K, Sawada H, Koskenvuo JW, Alvira C, Rabinovitch M, Alastalo TP. Vattulainen-Collanus S, et al. Among authors: alastalo tp. J Cell Sci. 2016 Feb 15;129(4):693-705. doi: 10.1242/jcs.169011. Epub 2016 Jan 7. J Cell Sci. 2016. PMID: 26743080 Free PMC article.
Suppression of endothelial CD39/ENTPD1 is associated with pulmonary vascular remodeling in pulmonary arterial hypertension.
Helenius MH, Vattulainen S, Orcholski M, Aho J, Komulainen A, Taimen P, Wang L, de Jesus Perez VA, Koskenvuo JW, Alastalo TP. Helenius MH, et al. Among authors: alastalo tp. Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1046-57. doi: 10.1152/ajplung.00340.2014. Epub 2015 Mar 27. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25820525 Free article. Clinical Trial.
55 results