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Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead.
Du H, Matsushima T, Spyvee M, Goto M, Shirota H, Gusovsky F, Chiba K, Kotake M, Yoneda N, Eguchi Y, DiPietro L, Harmange JC, Gilbert S, Li XY, Davis H, Jiang Y, Zhang Z, Pelletier R, Wong N, Sakurai H, Yang H, Ito-Igarashi H, Kimura A, Kuboi Y, Mizui Y, Tanaka I, Ikemori-Kawada M, Kawakami Y, Inoue A, Kawai T, Kishi Y, Wang Y. Du H, et al. Among authors: kuboi y. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6196-9. doi: 10.1016/j.bmcl.2009.08.096. Epub 2009 Sep 3. Bioorg Med Chem Lett. 2009. PMID: 19783437
E6201, a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-1 and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase-1: in vivo effects on cutaneous inflammatory responses by topical administration.
Muramoto K, Goto M, Inoue Y, Ishii N, Chiba K, Kuboi Y, Omae T, Wang YJ, Gusovsky F, Shirota H. Muramoto K, et al. Among authors: kuboi y. J Pharmacol Exp Ther. 2010 Oct;335(1):23-31. doi: 10.1124/jpet.110.168583. Epub 2010 Jul 13. J Pharmacol Exp Ther. 2010. PMID: 20627998
Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease.
Ohkuro M, Kim JD, Kuboi Y, Hayashi Y, Mizukami H, Kobayashi-Kuramochi H, Muramoto K, Shirato M, Michikawa-Tanaka F, Moriya J, Kozaki T, Takase K, Chiba K, Agarwala KL, Kimura T, Kotake M, Kawahara T, Yoneda N, Hirota S, Azuma H, Ozasa-Komura N, Ohashi Y, Muratani M, Kimura K, Hishinuma I, Fukamizu A. Ohkuro M, et al. Among authors: kuboi y. Nat Commun. 2018 May 17;9(1):1982. doi: 10.1038/s41467-018-04420-4. Nat Commun. 2018. PMID: 29773794 Free PMC article.
Role of Anti-Fractalkine Antibody in Suppression of Joint Destruction by Inhibiting Migration of Osteoclast Precursors to the Synovium in Experimental Arthritis.
Hoshino-Negishi K, Ohkuro M, Nakatani T, Kuboi Y, Nishimura M, Ida Y, Kakuta J, Hamaguchi A, Kumai M, Kamisako T, Sugiyama F, Ikeda W, Ishii N, Yasuda N, Imai T. Hoshino-Negishi K, et al. Among authors: kuboi y. Arthritis Rheumatol. 2019 Feb;71(2):222-231. doi: 10.1002/art.40688. Arthritis Rheumatol. 2019. PMID: 30079992
Inhibition of the Progression of Skin Inflammation, Fibrosis, and Vascular Injury by Blockade of the CX3 CL1/CX3 CR1 Pathway in Experimental Mouse Models of Systemic Sclerosis.
Luong VH, Utsunomiya A, Chino T, Doanh LH, Matsushita T, Obara T, Kuboi Y, Ishii N, Machinaga A, Ogasawara H, Ikeda W, Kawano T, Imai T, Oyama N, Hasegawa M. Luong VH, et al. Among authors: kuboi y. Arthritis Rheumatol. 2019 Nov;71(11):1923-1934. doi: 10.1002/art.41009. Epub 2019 Sep 11. Arthritis Rheumatol. 2019. PMID: 31173491
106 results